Association of redox status and lifestyle factors with telomere length in healthy subjects
Апстракт
Telomeres are DNA-protein structures located at the ends of eukaryotic chromosomes. Since
their shortening is a natural process, which repeats with each cell division, telomere lengths
have been proposed as a biomarker of aging. Also, there is evidence that telomere shortening
and dysfunction can be accelerated by oxidative-stress and unhealthy lifestyle factors,
including physical inactivity and inadequate nutrition, Thus, we aimed to evaluate the
association of redox status and selected lifestyle factors with telomere length. The study
included 94 apparently healthy adults, both genders with average age 46±12 years. Before
anthropometric measurements and venous blood sampling, participants were asked to complete
a lifestyle questionnaire. Serum antioxidant defense markers (total sulfhydryl groups,
paraoxonase activity and total antioxidant status) and prooxidants and products of its activity
(malondialdehyde, superoxide anion and total oxidant status) were determined. The
...Prooxidative score, Antioxidative score and Oxy score were calculated from measured redox
status markers by using z-score statistics. Telomere length was determined by qPCR method
using genomic DNA from peripheral blood leukocytes. A positive relation was found among
telomere length and a moderate level of physical activity, intake of fruits and vegetables,
especially for females. Increasing abdominal fat, alcohol and fried food intake, as well the Oxy
score (difference between Proxidative and Antioxidative scores) were inversely associated with
telomere length. Overall, these results support the impact of healthy lifestyle on healthy aging
and redox control in the term of prevention of major age-related diseases.
Извор:
Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade, 2020, 38-38Издавач:
- University of Belgrade, Belgrade, Serbia
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
Напомена:
- Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade, March 2-3, 2020
Институција/група
PharmacyTY - CONF AU - Ilić, Tijana AU - Vidović, Bojana AU - Kotur-Stevuljević, Jelena AU - Ostanek, Barbara PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5518 AB - Telomeres are DNA-protein structures located at the ends of eukaryotic chromosomes. Since their shortening is a natural process, which repeats with each cell division, telomere lengths have been proposed as a biomarker of aging. Also, there is evidence that telomere shortening and dysfunction can be accelerated by oxidative-stress and unhealthy lifestyle factors, including physical inactivity and inadequate nutrition, Thus, we aimed to evaluate the association of redox status and selected lifestyle factors with telomere length. The study included 94 apparently healthy adults, both genders with average age 46±12 years. Before anthropometric measurements and venous blood sampling, participants were asked to complete a lifestyle questionnaire. Serum antioxidant defense markers (total sulfhydryl groups, paraoxonase activity and total antioxidant status) and prooxidants and products of its activity (malondialdehyde, superoxide anion and total oxidant status) were determined. The Prooxidative score, Antioxidative score and Oxy score were calculated from measured redox status markers by using z-score statistics. Telomere length was determined by qPCR method using genomic DNA from peripheral blood leukocytes. A positive relation was found among telomere length and a moderate level of physical activity, intake of fruits and vegetables, especially for females. Increasing abdominal fat, alcohol and fried food intake, as well the Oxy score (difference between Proxidative and Antioxidative scores) were inversely associated with telomere length. Overall, these results support the impact of healthy lifestyle on healthy aging and redox control in the term of prevention of major age-related diseases. PB - University of Belgrade, Belgrade, Serbia C3 - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade T1 - Association of redox status and lifestyle factors with telomere length in healthy subjects SP - 38 EP - 38 UR - https://hdl.handle.net/21.15107/rcub_farfar_5518 ER -
@conference{ author = "Ilić, Tijana and Vidović, Bojana and Kotur-Stevuljević, Jelena and Ostanek, Barbara", year = "2020", abstract = "Telomeres are DNA-protein structures located at the ends of eukaryotic chromosomes. Since their shortening is a natural process, which repeats with each cell division, telomere lengths have been proposed as a biomarker of aging. Also, there is evidence that telomere shortening and dysfunction can be accelerated by oxidative-stress and unhealthy lifestyle factors, including physical inactivity and inadequate nutrition, Thus, we aimed to evaluate the association of redox status and selected lifestyle factors with telomere length. The study included 94 apparently healthy adults, both genders with average age 46±12 years. Before anthropometric measurements and venous blood sampling, participants were asked to complete a lifestyle questionnaire. Serum antioxidant defense markers (total sulfhydryl groups, paraoxonase activity and total antioxidant status) and prooxidants and products of its activity (malondialdehyde, superoxide anion and total oxidant status) were determined. The Prooxidative score, Antioxidative score and Oxy score were calculated from measured redox status markers by using z-score statistics. Telomere length was determined by qPCR method using genomic DNA from peripheral blood leukocytes. A positive relation was found among telomere length and a moderate level of physical activity, intake of fruits and vegetables, especially for females. Increasing abdominal fat, alcohol and fried food intake, as well the Oxy score (difference between Proxidative and Antioxidative scores) were inversely associated with telomere length. Overall, these results support the impact of healthy lifestyle on healthy aging and redox control in the term of prevention of major age-related diseases.", publisher = "University of Belgrade, Belgrade, Serbia", journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade", title = "Association of redox status and lifestyle factors with telomere length in healthy subjects", pages = "38-38", url = "https://hdl.handle.net/21.15107/rcub_farfar_5518" }
Ilić, T., Vidović, B., Kotur-Stevuljević, J.,& Ostanek, B.. (2020). Association of redox status and lifestyle factors with telomere length in healthy subjects. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade University of Belgrade, Belgrade, Serbia., 38-38. https://hdl.handle.net/21.15107/rcub_farfar_5518
Ilić T, Vidović B, Kotur-Stevuljević J, Ostanek B. Association of redox status and lifestyle factors with telomere length in healthy subjects. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:38-38. https://hdl.handle.net/21.15107/rcub_farfar_5518 .
Ilić, Tijana, Vidović, Bojana, Kotur-Stevuljević, Jelena, Ostanek, Barbara, "Association of redox status and lifestyle factors with telomere length in healthy subjects" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):38-38, https://hdl.handle.net/21.15107/rcub_farfar_5518 .