Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions
Само за регистроване кориснике
2024
Аутори
Pavlović, DraganaDobrić, Silva
Stojanović, Nikola
Zlatković, Bojan
Matejić, Jelena
Kovačević, Nada
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of E. spiculifolia in vitro on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of E. spiculifolia applied at doses of 50–200 mg/kg p.o. exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent in vitro antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolatio...n, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity.
Кључне речи:
BSA / β-carotene bleaching assay / DPPH / Ericaceae / peritoneal macrophages / rat paw oedemaИзвор:
Natural Product Research, 2024Издавач:
- Taylor & Francis
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200113 (Универзитет у Нишу, Медицински факултет) (RS-MESTD-inst-2020-200113)
- Faculty of Medicine University of Niš Internal Scientific Project (No. 15)
DOI: 10.1080/14786419.2023.2301677
ISSN: 1478-6419
PubMed: 38206132
WoS: 001141584900001
Scopus: 2-s2.0-85182189713
Институција/група
PharmacyTY - JOUR AU - Pavlović, Dragana AU - Dobrić, Silva AU - Stojanović, Nikola AU - Zlatković, Bojan AU - Matejić, Jelena AU - Kovačević, Nada PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5568 AB - There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of E. spiculifolia in vitro on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of E. spiculifolia applied at doses of 50–200 mg/kg p.o. exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent in vitro antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolation, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity. PB - Taylor & Francis T2 - Natural Product Research T1 - Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions DO - 10.1080/14786419.2023.2301677 ER -
@article{ author = "Pavlović, Dragana and Dobrić, Silva and Stojanović, Nikola and Zlatković, Bojan and Matejić, Jelena and Kovačević, Nada", year = "2024", abstract = "There is little data on the phytochemical/pharmacological properties of Erica spiculifolia Salisb. (syn. Bruckentalia spiculifolia (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of E. spiculifolia in vitro on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of E. spiculifolia applied at doses of 50–200 mg/kg p.o. exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent in vitro antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolation, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity.", publisher = "Taylor & Francis", journal = "Natural Product Research", title = "Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions", doi = "10.1080/14786419.2023.2301677" }
Pavlović, D., Dobrić, S., Stojanović, N., Zlatković, B., Matejić, J.,& Kovačević, N.. (2024). Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions. in Natural Product Research Taylor & Francis.. https://doi.org/10.1080/14786419.2023.2301677
Pavlović D, Dobrić S, Stojanović N, Zlatković B, Matejić J, Kovačević N. Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions. in Natural Product Research. 2024;. doi:10.1080/14786419.2023.2301677 .
Pavlović, Dragana, Dobrić, Silva, Stojanović, Nikola, Zlatković, Bojan, Matejić, Jelena, Kovačević, Nada, "Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions" in Natural Product Research (2024), https://doi.org/10.1080/14786419.2023.2301677 . .