Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges
Аутори
Sopić, MironKaraduzovic-Hadziabdic, Kanita
Kardassis, Dimitris
Maegdefessel, Lars
Martelli, Fabio
Meerson, Ari
Munjas, Jelena
Niculescu, Loredan S.
Stoll, Monika
Magni, Paolo
Devaux, Yvan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a powerful tool for unravelling the complex molecular pathways that drive atherosclerosis. However, low reproducibility of research findings and lack of standardization of procedures pose significant challenges in this field. In this review, we discuss how transcriptomic research can help in understanding the different phenotypes of the atherosclerotic plaque that contribute to the development and progression of atherosclerosis. We highlight the methodological challenges that need to be addressed to improve research outputs, and emphasize the importance of research protocols harmonization. We also discuss recent advances in transcriptomic research, including bulk or single-cell sequencing, and their added value in plaque phenotyping. Finally, we explore how... integrated multiomics data and machine learning improve understanding of atherosclerosis and provide directions for future research.
Кључне речи:
Atherosclerotic plaque / Transcriptomics / Data integration / machine learningИзвор:
Journal of Molecular and Cellular Cardiology Plus, 2023, 6, 100048-Издавач:
- Elsevier Ltd.
Финансирање / пројекти:
- CardioRNA COST Action CA17129
- AtheroNET COST Action CA21153
Институција/група
PharmacyTY - JOUR AU - Sopić, Miron AU - Karaduzovic-Hadziabdic, Kanita AU - Kardassis, Dimitris AU - Maegdefessel, Lars AU - Martelli, Fabio AU - Meerson, Ari AU - Munjas, Jelena AU - Niculescu, Loredan S. AU - Stoll, Monika AU - Magni, Paolo AU - Devaux, Yvan PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5616 AB - Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a powerful tool for unravelling the complex molecular pathways that drive atherosclerosis. However, low reproducibility of research findings and lack of standardization of procedures pose significant challenges in this field. In this review, we discuss how transcriptomic research can help in understanding the different phenotypes of the atherosclerotic plaque that contribute to the development and progression of atherosclerosis. We highlight the methodological challenges that need to be addressed to improve research outputs, and emphasize the importance of research protocols harmonization. We also discuss recent advances in transcriptomic research, including bulk or single-cell sequencing, and their added value in plaque phenotyping. Finally, we explore how integrated multiomics data and machine learning improve understanding of atherosclerosis and provide directions for future research. PB - Elsevier Ltd. T2 - Journal of Molecular and Cellular Cardiology Plus T1 - Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges VL - 6 SP - 100048 DO - 10.1016/j.jmccpl.2023.100048 ER -
@article{ author = "Sopić, Miron and Karaduzovic-Hadziabdic, Kanita and Kardassis, Dimitris and Maegdefessel, Lars and Martelli, Fabio and Meerson, Ari and Munjas, Jelena and Niculescu, Loredan S. and Stoll, Monika and Magni, Paolo and Devaux, Yvan", year = "2023", abstract = "Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a powerful tool for unravelling the complex molecular pathways that drive atherosclerosis. However, low reproducibility of research findings and lack of standardization of procedures pose significant challenges in this field. In this review, we discuss how transcriptomic research can help in understanding the different phenotypes of the atherosclerotic plaque that contribute to the development and progression of atherosclerosis. We highlight the methodological challenges that need to be addressed to improve research outputs, and emphasize the importance of research protocols harmonization. We also discuss recent advances in transcriptomic research, including bulk or single-cell sequencing, and their added value in plaque phenotyping. Finally, we explore how integrated multiomics data and machine learning improve understanding of atherosclerosis and provide directions for future research.", publisher = "Elsevier Ltd.", journal = "Journal of Molecular and Cellular Cardiology Plus", title = "Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges", volume = "6", pages = "100048", doi = "10.1016/j.jmccpl.2023.100048" }
Sopić, M., Karaduzovic-Hadziabdic, K., Kardassis, D., Maegdefessel, L., Martelli, F., Meerson, A., Munjas, J., Niculescu, L. S., Stoll, M., Magni, P.,& Devaux, Y.. (2023). Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges. in Journal of Molecular and Cellular Cardiology Plus Elsevier Ltd.., 6, 100048. https://doi.org/10.1016/j.jmccpl.2023.100048
Sopić M, Karaduzovic-Hadziabdic K, Kardassis D, Maegdefessel L, Martelli F, Meerson A, Munjas J, Niculescu LS, Stoll M, Magni P, Devaux Y. Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges. in Journal of Molecular and Cellular Cardiology Plus. 2023;6:100048. doi:10.1016/j.jmccpl.2023.100048 .
Sopić, Miron, Karaduzovic-Hadziabdic, Kanita, Kardassis, Dimitris, Maegdefessel, Lars, Martelli, Fabio, Meerson, Ari, Munjas, Jelena, Niculescu, Loredan S., Stoll, Monika, Magni, Paolo, Devaux, Yvan, "Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges" in Journal of Molecular and Cellular Cardiology Plus, 6 (2023):100048, https://doi.org/10.1016/j.jmccpl.2023.100048 . .