Circulating Fatty Acids Associate with Metabolic Changes in Adolescents Living with Obesity
Autori
Subošić, BrankoKotur-Stevuljević, Jelena
Bogavac-Stanojević, Nataša
Zdravković, Vera
Ješić, Maja
Kovačević, Smiljka
Đuričić, Ivana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Fatty acids play a crucial role in obesity development and in the comorbidities of obesity in both adults and children. This study aimed to assess the impact of circulating fatty acids on biomarkers of metabolic health of adolescents living with obesity. Parameters such as blood lipids, redox status, and leukocyte telomere length (rLTL) were measured alongside the proportions of individual fatty acids. The Mann–Whitney U test revealed that individuals with obesity exhibited an unfavorable lipid and redox status compared to the control normal weight group. The group with obesity also had lower plasma n-3 polyunsaturated fatty acids (PUFAs) and a higher ratio of n-6 to n-3 PUFAs than the control group. They also had a shorter rLTL, indicating accelerated biological aging. There was an inverse association of rLTL and plasma n-6-to-n-3 PUFA ratio. Future studies should explore the impact of recommended nutrition plans and increased physical activity on these parameters to determine if thes...e interventions can enhance the health and well-being of adolescents with obesity, knowing that early obesity can track into adulthood.
Ključne reči:
telomere length / fatty acids / redox status / childhood obesity / lipidsIzvor:
Biomedicines, 12, 4Izdavač:
- MDPI
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200161 (Univerzitet u Beogradu, Farmaceutski fakultet) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/biomedicines12040883
ISSN: 2227-9059
PubMed: 38672237
Scopus: 2-s2.0-85191518644
Institucija/grupa
PharmacyTY - JOUR AU - Subošić, Branko AU - Kotur-Stevuljević, Jelena AU - Bogavac-Stanojević, Nataša AU - Zdravković, Vera AU - Ješić, Maja AU - Kovačević, Smiljka AU - Đuričić, Ivana UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5625 AB - Fatty acids play a crucial role in obesity development and in the comorbidities of obesity in both adults and children. This study aimed to assess the impact of circulating fatty acids on biomarkers of metabolic health of adolescents living with obesity. Parameters such as blood lipids, redox status, and leukocyte telomere length (rLTL) were measured alongside the proportions of individual fatty acids. The Mann–Whitney U test revealed that individuals with obesity exhibited an unfavorable lipid and redox status compared to the control normal weight group. The group with obesity also had lower plasma n-3 polyunsaturated fatty acids (PUFAs) and a higher ratio of n-6 to n-3 PUFAs than the control group. They also had a shorter rLTL, indicating accelerated biological aging. There was an inverse association of rLTL and plasma n-6-to-n-3 PUFA ratio. Future studies should explore the impact of recommended nutrition plans and increased physical activity on these parameters to determine if these interventions can enhance the health and well-being of adolescents with obesity, knowing that early obesity can track into adulthood. PB - MDPI T2 - Biomedicines T1 - Circulating Fatty Acids Associate with Metabolic Changes in Adolescents Living with Obesity VL - 12 IS - 4 DO - 10.3390/biomedicines12040883 ER -
@article{ author = "Subošić, Branko and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Zdravković, Vera and Ješić, Maja and Kovačević, Smiljka and Đuričić, Ivana", abstract = "Fatty acids play a crucial role in obesity development and in the comorbidities of obesity in both adults and children. This study aimed to assess the impact of circulating fatty acids on biomarkers of metabolic health of adolescents living with obesity. Parameters such as blood lipids, redox status, and leukocyte telomere length (rLTL) were measured alongside the proportions of individual fatty acids. The Mann–Whitney U test revealed that individuals with obesity exhibited an unfavorable lipid and redox status compared to the control normal weight group. The group with obesity also had lower plasma n-3 polyunsaturated fatty acids (PUFAs) and a higher ratio of n-6 to n-3 PUFAs than the control group. They also had a shorter rLTL, indicating accelerated biological aging. There was an inverse association of rLTL and plasma n-6-to-n-3 PUFA ratio. Future studies should explore the impact of recommended nutrition plans and increased physical activity on these parameters to determine if these interventions can enhance the health and well-being of adolescents with obesity, knowing that early obesity can track into adulthood.", publisher = "MDPI", journal = "Biomedicines", title = "Circulating Fatty Acids Associate with Metabolic Changes in Adolescents Living with Obesity", volume = "12", number = "4", doi = "10.3390/biomedicines12040883" }
Subošić, B., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Zdravković, V., Ješić, M., Kovačević, S.,& Đuričić, I..Circulating Fatty Acids Associate with Metabolic Changes in Adolescents Living with Obesity. in Biomedicines MDPI., 12(4). https://doi.org/10.3390/biomedicines12040883
Subošić B, Kotur-Stevuljević J, Bogavac-Stanojević N, Zdravković V, Ješić M, Kovačević S, Đuričić I. Circulating Fatty Acids Associate with Metabolic Changes in Adolescents Living with Obesity. in Biomedicines.12(4). doi:10.3390/biomedicines12040883 .
Subošić, Branko, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Zdravković, Vera, Ješić, Maja, Kovačević, Smiljka, Đuričić, Ivana, "Circulating Fatty Acids Associate with Metabolic Changes in Adolescents Living with Obesity" in Biomedicines, 12, no. 4, https://doi.org/10.3390/biomedicines12040883 . .