Cytotoxic prenylated phenols of false indigo-bush (Amorpha fruticosa L.)
Само за регистроване кориснике
2024
Аутори
Samardžić, Stevan![](/themes/MirageFarFaR/images/orcid.png)
Đorđić Crnogorac, Marija
Petković, Miloš
![](/themes/MirageFarFaR/images/orcid.png)
Arsenijević, Jelena
![](/themes/MirageFarFaR/images/orcid.png)
Stanojković, Tatjana
![](/themes/MirageFarFaR/images/orcid.png)
Maksimović, Zoran
![](/themes/MirageFarFaR/images/orcid.png)
Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
This study employed the MTT assay to assess the cytotoxicity of one flavan and two stilbene derivatives isolated from the false indigo-bush (Amorpha fruticosa L.) fruits: 5,7-dihydroxy-8-geranylflavanone (1), 2-carboxy-3,5-dihydroxy-4-geranylbibenzyl (2), and 2-carboxy-3-hydroxy-
4-prenyl-5-methoxybibenzyl (3). The examined compounds reduced the survival of human cervical and colon tumour cells (HeLa, HT-29, HCT-116, and LS174) with IC50 values ranging from 10.55 to 147.09 μg/mL, except for 1, which did not affect LS174 cells within the tested concentrations. The highest activity was observed for 1 against HeLa cells, and 1 also exhibited the weakest effect against normal foetal lung fibroblasts (IC50 = 166.11 μg/mL), demonstrating good potency and selectivity. Stilbenes 2 and 3 proved efficacious, but lacked selectivity compared to 1. Our findings revealed the cytotoxicity of false indigo-bush constituents, justifying further mechanistic and in vivo investigations, particularly on 5,...7-dihydroxy-8-geranylflavanone, which displayed considerable in vitro anticancer capacity and a potentially favourable safety profile.
Кључне речи:
Amorpha fruticosa / prenylated phenols / 5,7-dihydroxy-8- geranylflavanone / 2-carboxy-3,5-dihydroxy- 4-geranylbibenzyl / amorfrutin A / cytotoxic activityИзвор:
Natural Product Research, 2024Издавач:
- Taylor & Francis Ltd.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200043 (Институт за онкологију и радиологију Србије, Београд) (RS-MESTD-inst-2020-200043)
DOI: 10.1080/14786419.2024.2353912
ISSN: 1478-6419
PubMed: 38733625
Scopus: 2-s2.0-85192719618
Институција/група
PharmacyTY - JOUR AU - Samardžić, Stevan AU - Đorđić Crnogorac, Marija AU - Petković, Miloš AU - Arsenijević, Jelena AU - Stanojković, Tatjana AU - Maksimović, Zoran PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5636 AB - This study employed the MTT assay to assess the cytotoxicity of one flavan and two stilbene derivatives isolated from the false indigo-bush (Amorpha fruticosa L.) fruits: 5,7-dihydroxy-8-geranylflavanone (1), 2-carboxy-3,5-dihydroxy-4-geranylbibenzyl (2), and 2-carboxy-3-hydroxy- 4-prenyl-5-methoxybibenzyl (3). The examined compounds reduced the survival of human cervical and colon tumour cells (HeLa, HT-29, HCT-116, and LS174) with IC50 values ranging from 10.55 to 147.09 μg/mL, except for 1, which did not affect LS174 cells within the tested concentrations. The highest activity was observed for 1 against HeLa cells, and 1 also exhibited the weakest effect against normal foetal lung fibroblasts (IC50 = 166.11 μg/mL), demonstrating good potency and selectivity. Stilbenes 2 and 3 proved efficacious, but lacked selectivity compared to 1. Our findings revealed the cytotoxicity of false indigo-bush constituents, justifying further mechanistic and in vivo investigations, particularly on 5,7-dihydroxy-8-geranylflavanone, which displayed considerable in vitro anticancer capacity and a potentially favourable safety profile. PB - Taylor & Francis Ltd. T2 - Natural Product Research T1 - Cytotoxic prenylated phenols of false indigo-bush (Amorpha fruticosa L.) DO - 10.1080/14786419.2024.2353912 ER -
@article{ author = "Samardžić, Stevan and Đorđić Crnogorac, Marija and Petković, Miloš and Arsenijević, Jelena and Stanojković, Tatjana and Maksimović, Zoran", year = "2024", abstract = "This study employed the MTT assay to assess the cytotoxicity of one flavan and two stilbene derivatives isolated from the false indigo-bush (Amorpha fruticosa L.) fruits: 5,7-dihydroxy-8-geranylflavanone (1), 2-carboxy-3,5-dihydroxy-4-geranylbibenzyl (2), and 2-carboxy-3-hydroxy- 4-prenyl-5-methoxybibenzyl (3). The examined compounds reduced the survival of human cervical and colon tumour cells (HeLa, HT-29, HCT-116, and LS174) with IC50 values ranging from 10.55 to 147.09 μg/mL, except for 1, which did not affect LS174 cells within the tested concentrations. The highest activity was observed for 1 against HeLa cells, and 1 also exhibited the weakest effect against normal foetal lung fibroblasts (IC50 = 166.11 μg/mL), demonstrating good potency and selectivity. Stilbenes 2 and 3 proved efficacious, but lacked selectivity compared to 1. Our findings revealed the cytotoxicity of false indigo-bush constituents, justifying further mechanistic and in vivo investigations, particularly on 5,7-dihydroxy-8-geranylflavanone, which displayed considerable in vitro anticancer capacity and a potentially favourable safety profile.", publisher = "Taylor & Francis Ltd.", journal = "Natural Product Research", title = "Cytotoxic prenylated phenols of false indigo-bush (Amorpha fruticosa L.)", doi = "10.1080/14786419.2024.2353912" }
Samardžić, S., Đorđić Crnogorac, M., Petković, M., Arsenijević, J., Stanojković, T.,& Maksimović, Z.. (2024). Cytotoxic prenylated phenols of false indigo-bush (Amorpha fruticosa L.). in Natural Product Research Taylor & Francis Ltd... https://doi.org/10.1080/14786419.2024.2353912
Samardžić S, Đorđić Crnogorac M, Petković M, Arsenijević J, Stanojković T, Maksimović Z. Cytotoxic prenylated phenols of false indigo-bush (Amorpha fruticosa L.). in Natural Product Research. 2024;. doi:10.1080/14786419.2024.2353912 .
Samardžić, Stevan, Đorđić Crnogorac, Marija, Petković, Miloš, Arsenijević, Jelena, Stanojković, Tatjana, Maksimović, Zoran, "Cytotoxic prenylated phenols of false indigo-bush (Amorpha fruticosa L.)" in Natural Product Research (2024), https://doi.org/10.1080/14786419.2024.2353912 . .