Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis
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The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.
Кључне речи:
diabetes / anti-diabetics / fungi / Fomes fomentarius / fomentariolИзвор:
Nutraceuticals, 2024, 4, 2, 273-282Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
Институција/група
PharmacyTY - JOUR AU - Ravnikar, Matjaž AU - Štrukelj, Borut AU - Otašević, Biljana AU - Sirše, Mateja PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5641 AB - The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans. PB - MDPI T2 - Nutraceuticals T1 - Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis VL - 4 IS - 2 SP - 273 EP - 282 DO - 10.3390/nutraceuticals4020017 ER -
@article{ author = "Ravnikar, Matjaž and Štrukelj, Borut and Otašević, Biljana and Sirše, Mateja", year = "2024", abstract = "The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.", publisher = "MDPI", journal = "Nutraceuticals", title = "Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis", volume = "4", number = "2", pages = "273-282", doi = "10.3390/nutraceuticals4020017" }
Ravnikar, M., Štrukelj, B., Otašević, B.,& Sirše, M.. (2024). Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis. in Nutraceuticals MDPI., 4(2), 273-282. https://doi.org/10.3390/nutraceuticals4020017
Ravnikar M, Štrukelj B, Otašević B, Sirše M. Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis. in Nutraceuticals. 2024;4(2):273-282. doi:10.3390/nutraceuticals4020017 .
Ravnikar, Matjaž, Štrukelj, Borut, Otašević, Biljana, Sirše, Mateja, "Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis" in Nutraceuticals, 4, no. 2 (2024):273-282, https://doi.org/10.3390/nutraceuticals4020017 . .