A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development
Само за регистроване кориснике
2024
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Orodispersible films (ODFs) have emerged as innovative pharmaceutical dosage forms, offering patient-specific treatment through adjustable dosing and the combination of diverse active ingredients. This expanding field generates vast datasets, requiring advanced analytical techniques for deeper understanding of data itself. Machine learning is becoming an important tool in the rapidly changing field of pharmaceutical research, particularly in drug preformulation studies. This work aims to explore into the application of machine learning methods for the analysis of experimental data obtained by ODF characterization in order to obtain an insight into the factors governing ODF performance and use it as guidance in pharmaceutical development. Using a dataset derived from extensive experimental studies, various machine learning algorithms were employed to cluster and predict critical properties of ODFs. Our results demonstrate that machine learning models, including Support vector machine, R...andom forest and Deep learning, exhibit high accuracy in predicting the mechanical properties of ODFs, such as flexibility and rigidity. The predictive models offered insights into the complex interaction of formulation variables. This research is a pilot study that highlights the potential of machine learning as a transformative approach in the pharmaceutical field, paving the way for more efficient and informed drug development processes.
Кључне речи:
Mechanical properties / Deep learning / Orodispersible films / Predictive models / Preformulation studies / Random forest / Support vector machineИзвор:
International Journal of Pharmaceutics, 2024, 658Издавач:
- Elsevier B.V.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.ijpharm.2024.124188
ISSN: 0378-5173
PubMed: 38705248
Scopus: 2-s2.0-85192498112
Институција/група
PharmacyTY - JOUR AU - Turković, Erna AU - Vasiljević, Ivana AU - Parojčić, Jelena PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5650 AB - Orodispersible films (ODFs) have emerged as innovative pharmaceutical dosage forms, offering patient-specific treatment through adjustable dosing and the combination of diverse active ingredients. This expanding field generates vast datasets, requiring advanced analytical techniques for deeper understanding of data itself. Machine learning is becoming an important tool in the rapidly changing field of pharmaceutical research, particularly in drug preformulation studies. This work aims to explore into the application of machine learning methods for the analysis of experimental data obtained by ODF characterization in order to obtain an insight into the factors governing ODF performance and use it as guidance in pharmaceutical development. Using a dataset derived from extensive experimental studies, various machine learning algorithms were employed to cluster and predict critical properties of ODFs. Our results demonstrate that machine learning models, including Support vector machine, Random forest and Deep learning, exhibit high accuracy in predicting the mechanical properties of ODFs, such as flexibility and rigidity. The predictive models offered insights into the complex interaction of formulation variables. This research is a pilot study that highlights the potential of machine learning as a transformative approach in the pharmaceutical field, paving the way for more efficient and informed drug development processes. PB - Elsevier B.V. T2 - International Journal of Pharmaceutics T1 - A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development VL - 658 DO - 10.1016/j.ijpharm.2024.124188 ER -
@article{ author = "Turković, Erna and Vasiljević, Ivana and Parojčić, Jelena", year = "2024", abstract = "Orodispersible films (ODFs) have emerged as innovative pharmaceutical dosage forms, offering patient-specific treatment through adjustable dosing and the combination of diverse active ingredients. This expanding field generates vast datasets, requiring advanced analytical techniques for deeper understanding of data itself. Machine learning is becoming an important tool in the rapidly changing field of pharmaceutical research, particularly in drug preformulation studies. This work aims to explore into the application of machine learning methods for the analysis of experimental data obtained by ODF characterization in order to obtain an insight into the factors governing ODF performance and use it as guidance in pharmaceutical development. Using a dataset derived from extensive experimental studies, various machine learning algorithms were employed to cluster and predict critical properties of ODFs. Our results demonstrate that machine learning models, including Support vector machine, Random forest and Deep learning, exhibit high accuracy in predicting the mechanical properties of ODFs, such as flexibility and rigidity. The predictive models offered insights into the complex interaction of formulation variables. This research is a pilot study that highlights the potential of machine learning as a transformative approach in the pharmaceutical field, paving the way for more efficient and informed drug development processes.", publisher = "Elsevier B.V.", journal = "International Journal of Pharmaceutics", title = "A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development", volume = "658", doi = "10.1016/j.ijpharm.2024.124188" }
Turković, E., Vasiljević, I.,& Parojčić, J.. (2024). A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development. in International Journal of Pharmaceutics Elsevier B.V.., 658. https://doi.org/10.1016/j.ijpharm.2024.124188
Turković E, Vasiljević I, Parojčić J. A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development. in International Journal of Pharmaceutics. 2024;658. doi:10.1016/j.ijpharm.2024.124188 .
Turković, Erna, Vasiljević, Ivana, Parojčić, Jelena, "A comprehensive assessment of machine learning algorithms for enhanced characterization and prediction in orodispersible film development" in International Journal of Pharmaceutics, 658 (2024), https://doi.org/10.1016/j.ijpharm.2024.124188 . .