Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC
Samo za registrovane korisnike
2005
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations.
Ključne reči:
column liquid chromatography / pharmaceutical formulations / benzyl alcohol / bifonazoleIzvor:
Chromatographia, 2005, 61, 7-8, 415-418Izdavač:
- Springer Heidelberg, Heidelberg
DOI: 10.1365/s10337-005-0524-9
ISSN: 0009-5893
WoS: 000228610300019
Scopus: 2-s2.0-17644393561
Institucija/grupa
PharmacyTY - JOUR AU - Čudina, Olivera AU - Comor, Mirjana AU - Janković, IA PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/588 AB - A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations. PB - Springer Heidelberg, Heidelberg T2 - Chromatographia T1 - Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC VL - 61 IS - 7-8 SP - 415 EP - 418 DO - 10.1365/s10337-005-0524-9 ER -
@article{ author = "Čudina, Olivera and Comor, Mirjana and Janković, IA", year = "2005", abstract = "A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations.", publisher = "Springer Heidelberg, Heidelberg", journal = "Chromatographia", title = "Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC", volume = "61", number = "7-8", pages = "415-418", doi = "10.1365/s10337-005-0524-9" }
Čudina, O., Comor, M.,& Janković, I.. (2005). Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC. in Chromatographia Springer Heidelberg, Heidelberg., 61(7-8), 415-418. https://doi.org/10.1365/s10337-005-0524-9
Čudina O, Comor M, Janković I. Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC. in Chromatographia. 2005;61(7-8):415-418. doi:10.1365/s10337-005-0524-9 .
Čudina, Olivera, Comor, Mirjana, Janković, IA, "Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC" in Chromatographia, 61, no. 7-8 (2005):415-418, https://doi.org/10.1365/s10337-005-0524-9 . .