Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide
Само за регистроване кориснике
2006
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3...) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination.
Кључне речи:
quinapril anion / CTAB / micelles / binding constant / partition coefficient / MLCИзвор:
Journal of Colloid and Interface Science, 2006, 301, 2, 692-696Издавач:
- Academic Press Inc Elsevier Science, San Diego
Финансирање / пројекти:
- Синтеза и карактеризација наночестица и нанокомпозита (RS-MESTD-MPN2006-2010-142066)
- Супстанце за фармацеутску употребу: моделирање, синтеза, физичко-хемијске и биолошке особине, степен чистоће и испитивање дозираних облика (RS-MESTD-MPN2006-2010-142072)
DOI: 10.1016/j.jcis.2006.05.025
ISSN: 0021-9797
PubMed: 16765977
WoS: 000239937700047
Scopus: 2-s2.0-33746926406
Институција/група
PharmacyTY - JOUR AU - Čudina, Olivera AU - Janković, Ivana AU - Comor, Mirjana AU - Vladimirov, Sote PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/712 AB - In this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination. PB - Academic Press Inc Elsevier Science, San Diego T2 - Journal of Colloid and Interface Science T1 - Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide VL - 301 IS - 2 SP - 692 EP - 696 DO - 10.1016/j.jcis.2006.05.025 ER -
@article{ author = "Čudina, Olivera and Janković, Ivana and Comor, Mirjana and Vladimirov, Sote", year = "2006", abstract = "In this study, the interaction of the anion of quinapril (QUIN), angiotensin converting enzyme (ACE) inhibitor, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of QUIN was studied at pH 8. The binding of QUIN anion to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.39) proving the great affinity of negatively charged QUIN ion for the positively charged CTAB micelle surface. The strong dependence of the partition coefficient K-x on QUIN concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 272 nm on CTAB concentration, by using mathematical model that treats the solubilization of QUIN anion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (2.3 +/- 0.4) x 10(3) mol(-1) dm(3) was obtained. QUIN-CTAB binding constant was also calculated from micellar liquid chromatography (MLC) and this method was found to be not accurate enough for its determination.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Journal of Colloid and Interface Science", title = "Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide", volume = "301", number = "2", pages = "692-696", doi = "10.1016/j.jcis.2006.05.025" }
Čudina, O., Janković, I., Comor, M.,& Vladimirov, S.. (2006). Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide. in Journal of Colloid and Interface Science Academic Press Inc Elsevier Science, San Diego., 301(2), 692-696. https://doi.org/10.1016/j.jcis.2006.05.025
Čudina O, Janković I, Comor M, Vladimirov S. Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide. in Journal of Colloid and Interface Science. 2006;301(2):692-696. doi:10.1016/j.jcis.2006.05.025 .
Čudina, Olivera, Janković, Ivana, Comor, Mirjana, Vladimirov, Sote, "Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide" in Journal of Colloid and Interface Science, 301, no. 2 (2006):692-696, https://doi.org/10.1016/j.jcis.2006.05.025 . .