An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier
Само за регистроване кориснике
2006
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Multiple W/O/W emulsions with high content of inner phase (Phi 1 = Phi 2 = 0.8) were prepared using relatively low concentrations of lipophilic polymeric primary emulsifier, PEG 30-dipolyhydroxystearate, and diclofenac diethylamine (DDA) as a model drug. The investigated formulations were characterized and their stability over the time was evaluated by dynamic and oscillatory rheological measurements, microscopic analysis and in vitro drug release study. In vitro release profiles of the selected model drug were evaluated in terms of the effective diffusion coefficients and flux of the released drug. The multiple emulsion samples exhibited good stability during the ageing time. Concentration of the lipophilic primary emulsifier markedly affected rheological behaviour as well as the droplet size and in vitro drug release kinetics of the investigated systems. The multiple emulsion systems with highest concentration (2.4%, w/w) of the primary emulsifier had the lowest droplet size and the ...highest apparent viscosity and highest elastic characteristics. Drug release data indicated predominately diffusional drug release mechanism with sustained and prolonged drug release accomplished with 2.4% (w/w) of lipophilic emulsifier employed.
Кључне речи:
W/O/W emulsions / rheology / droplet size / in vitro release / diclofenac diethylamineИзвор:
International Journal of Pharmaceutics, 2006, 309, 1-2, 171-177Издавач:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.ijpharm.2005.11.034
ISSN: 0378-5173
PubMed: 16406403
WoS: 000235571400023
Scopus: 2-s2.0-31144475104
Институција/група
PharmacyTY - JOUR AU - Vasiljević, D AU - Parojčić, Jelena AU - Primorac, Marija AU - Vuleta, G PY - 2006 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/842 AB - Multiple W/O/W emulsions with high content of inner phase (Phi 1 = Phi 2 = 0.8) were prepared using relatively low concentrations of lipophilic polymeric primary emulsifier, PEG 30-dipolyhydroxystearate, and diclofenac diethylamine (DDA) as a model drug. The investigated formulations were characterized and their stability over the time was evaluated by dynamic and oscillatory rheological measurements, microscopic analysis and in vitro drug release study. In vitro release profiles of the selected model drug were evaluated in terms of the effective diffusion coefficients and flux of the released drug. The multiple emulsion samples exhibited good stability during the ageing time. Concentration of the lipophilic primary emulsifier markedly affected rheological behaviour as well as the droplet size and in vitro drug release kinetics of the investigated systems. The multiple emulsion systems with highest concentration (2.4%, w/w) of the primary emulsifier had the lowest droplet size and the highest apparent viscosity and highest elastic characteristics. Drug release data indicated predominately diffusional drug release mechanism with sustained and prolonged drug release accomplished with 2.4% (w/w) of lipophilic emulsifier employed. PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier VL - 309 IS - 1-2 SP - 171 EP - 177 DO - 10.1016/j.ijpharm.2005.11.034 ER -
@article{ author = "Vasiljević, D and Parojčić, Jelena and Primorac, Marija and Vuleta, G", year = "2006", abstract = "Multiple W/O/W emulsions with high content of inner phase (Phi 1 = Phi 2 = 0.8) were prepared using relatively low concentrations of lipophilic polymeric primary emulsifier, PEG 30-dipolyhydroxystearate, and diclofenac diethylamine (DDA) as a model drug. The investigated formulations were characterized and their stability over the time was evaluated by dynamic and oscillatory rheological measurements, microscopic analysis and in vitro drug release study. In vitro release profiles of the selected model drug were evaluated in terms of the effective diffusion coefficients and flux of the released drug. The multiple emulsion samples exhibited good stability during the ageing time. Concentration of the lipophilic primary emulsifier markedly affected rheological behaviour as well as the droplet size and in vitro drug release kinetics of the investigated systems. The multiple emulsion systems with highest concentration (2.4%, w/w) of the primary emulsifier had the lowest droplet size and the highest apparent viscosity and highest elastic characteristics. Drug release data indicated predominately diffusional drug release mechanism with sustained and prolonged drug release accomplished with 2.4% (w/w) of lipophilic emulsifier employed.", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier", volume = "309", number = "1-2", pages = "171-177", doi = "10.1016/j.ijpharm.2005.11.034" }
Vasiljević, D., Parojčić, J., Primorac, M.,& Vuleta, G.. (2006). An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 309(1-2), 171-177. https://doi.org/10.1016/j.ijpharm.2005.11.034
Vasiljević D, Parojčić J, Primorac M, Vuleta G. An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier. in International Journal of Pharmaceutics. 2006;309(1-2):171-177. doi:10.1016/j.ijpharm.2005.11.034 .
Vasiljević, D, Parojčić, Jelena, Primorac, Marija, Vuleta, G, "An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier" in International Journal of Pharmaceutics, 309, no. 1-2 (2006):171-177, https://doi.org/10.1016/j.ijpharm.2005.11.034 . .