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Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors
dc.creator | Tomić, Maja | |
dc.creator | Vučković, Sonja M. | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Ugrešić, Nenad | |
dc.creator | Prostran, Milica | |
dc.creator | Bošković, Bogdan | |
dc.date.accessioned | 2019-09-02T11:07:54Z | |
dc.date.available | 2019-09-02T11:07:54Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0031-7144 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/858 | |
dc.description.abstract | In this study we determined whether oxcarbazepine (OXC) could produce local peripheral antinociceptive effects in a rat model of inflammatory hyperalgesia, and whether adenosine receptors were involved. When coadministered with the pro-inflammatory compound concanavalin A, OXC (1000-3000 nmol/paw) caused a significant dose- and time-dependent anti-hyperalgesia. Caffeine (1000-1500 nmol/paw), a nonselective adenosine receptor antagonist, as well as 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) (10-30 nmol/paw), a selective A, receptor antagonist, coadministered with OXC, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results indicate that OXC produces local peripheral anti-hyperalgesic effects, which is mediated via peripheral A, receptors. | en |
dc.publisher | Govi-Verlag Pharmazeutischer Verlag Gmbh, Eschborn | |
dc.rights | restrictedAccess | |
dc.source | Pharmazie | |
dc.title | Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A(1) receptors | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Простран, Милица; Вучковић, Соња М.; Бошковић, Богдан; Угрешић, Ненад; Томић, Маја; Степановић-Петровић, Радица; | |
dc.citation.volume | 61 | |
dc.citation.issue | 6 | |
dc.citation.spage | 566 | |
dc.citation.epage | 568 | |
dc.citation.other | 61(6): 566-568 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000238320300016 | |
dc.identifier.pmid | 16826981 | |
dc.identifier.scopus | 2-s2.0-33745624612 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_858 | |
dc.type.version | publishedVersion |
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