Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine
Nema prikaza
Autori
Stepanović-Petrović, RadicaTomić, Maja
Vučković, Sonja M.
Ugrešić, Nenad
Prostran, Milica
Bošković, B
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The mechanisms of the analgesic action of carbamazepine and oxcarbazepine, in particular the role of opioid receptors, have not been established precisely. The systemic effects of naloxone, an opioid receptor antagonist, on the antihyperalgesic effects of carbamazepine and oxcarbazepine were examined in the model of inflammatory hyperalgesia induced by the intraplantar (i.pl.) administration of concanavaline A (Con A, 0.8 mg/paw) into the rat hind paw. Naloxone (3 mg/kg; i.p.) did not alter the antihyperalgesic effects of either carbamazepine or axcarbazepine. These results indicate that the opioid system of pain modulation does not play a significant role in the antihyperalgesic effects of carbamazepine and oxcarbazepine.
Ključne reči:
carbamazepine / inflammatory hyperalgesia / naloxone / opioid receptors / oxcarbazepineIzvor:
Methods and Findings in Experimental and Clinical Pharmacology, 2007, 29, 3, 191-194Izdavač:
- Prous Science, Sau-Thomson Reuters, Barcelona
DOI: 10.1358/mf.2007.29.3.1075352
ISSN: 0379-0355
PubMed: 17520100
WoS: 000246979400003
Scopus: 2-s2.0-34250353535
Institucija/grupa
PharmacyTY - JOUR AU - Stepanović-Petrović, Radica AU - Tomić, Maja AU - Vučković, Sonja M. AU - Ugrešić, Nenad AU - Prostran, Milica AU - Bošković, B PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/924 AB - The mechanisms of the analgesic action of carbamazepine and oxcarbazepine, in particular the role of opioid receptors, have not been established precisely. The systemic effects of naloxone, an opioid receptor antagonist, on the antihyperalgesic effects of carbamazepine and oxcarbazepine were examined in the model of inflammatory hyperalgesia induced by the intraplantar (i.pl.) administration of concanavaline A (Con A, 0.8 mg/paw) into the rat hind paw. Naloxone (3 mg/kg; i.p.) did not alter the antihyperalgesic effects of either carbamazepine or axcarbazepine. These results indicate that the opioid system of pain modulation does not play a significant role in the antihyperalgesic effects of carbamazepine and oxcarbazepine. PB - Prous Science, Sau-Thomson Reuters, Barcelona T2 - Methods and Findings in Experimental and Clinical Pharmacology T1 - Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine VL - 29 IS - 3 SP - 191 EP - 194 DO - 10.1358/mf.2007.29.3.1075352 ER -
@article{ author = "Stepanović-Petrović, Radica and Tomić, Maja and Vučković, Sonja M. and Ugrešić, Nenad and Prostran, Milica and Bošković, B", year = "2007", abstract = "The mechanisms of the analgesic action of carbamazepine and oxcarbazepine, in particular the role of opioid receptors, have not been established precisely. The systemic effects of naloxone, an opioid receptor antagonist, on the antihyperalgesic effects of carbamazepine and oxcarbazepine were examined in the model of inflammatory hyperalgesia induced by the intraplantar (i.pl.) administration of concanavaline A (Con A, 0.8 mg/paw) into the rat hind paw. Naloxone (3 mg/kg; i.p.) did not alter the antihyperalgesic effects of either carbamazepine or axcarbazepine. These results indicate that the opioid system of pain modulation does not play a significant role in the antihyperalgesic effects of carbamazepine and oxcarbazepine.", publisher = "Prous Science, Sau-Thomson Reuters, Barcelona", journal = "Methods and Findings in Experimental and Clinical Pharmacology", title = "Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine", volume = "29", number = "3", pages = "191-194", doi = "10.1358/mf.2007.29.3.1075352" }
Stepanović-Petrović, R., Tomić, M., Vučković, S. M., Ugrešić, N., Prostran, M.,& Bošković, B.. (2007). Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine. in Methods and Findings in Experimental and Clinical Pharmacology Prous Science, Sau-Thomson Reuters, Barcelona., 29(3), 191-194. https://doi.org/10.1358/mf.2007.29.3.1075352
Stepanović-Petrović R, Tomić M, Vučković SM, Ugrešić N, Prostran M, Bošković B. Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine. in Methods and Findings in Experimental and Clinical Pharmacology. 2007;29(3):191-194. doi:10.1358/mf.2007.29.3.1075352 .
Stepanović-Petrović, Radica, Tomić, Maja, Vučković, Sonja M., Ugrešić, Nenad, Prostran, Milica, Bošković, B, "Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine" in Methods and Findings in Experimental and Clinical Pharmacology, 29, no. 3 (2007):191-194, https://doi.org/10.1358/mf.2007.29.3.1075352 . .