Приказ основних података о документу
Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands
dc.creator | Erić, Slavica | |
dc.creator | Pavlović, A. | |
dc.creator | Popović, Gordana | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-02T11:10:18Z | |
dc.date.available | 2019-09-02T11:10:18Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0021-9665 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/952 | |
dc.description.abstract | The retention constant (110) is determined for 11 selected adrenergic and imidazoline receptor ligands by reverse-phase-thin layer chromatography. It is established that the retention behavior of investigated compounds mostly depends on geometrical, electrostatic, and hydrogen bonding properties. Good correlations among hydrophobic parameters R-m(0) versus log P for all eleven tested compounds are obtained. The satisfactory correlations are found between R-m(0) versus apparent partition coefficient octanol-buffer pH 7.4 (log P-1) or apparent partition coefficient in four liposome systems (log K-M(1)) and hypotensive activity (pC(25)) for five imidazolines. The results confirm the suitability of this parameter in quantitative structure-property and structure-activity relationships studies of these drugs. | en |
dc.publisher | Oxford Univ Press Inc, Cary | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Chromatographic Science | |
dc.title | Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Поповић, Гордана; Ерић, Славица; Павловић, A.; Aгбаба, Даница; | |
dc.citation.volume | 45 | |
dc.citation.issue | 3 | |
dc.citation.spage | 140 | |
dc.citation.epage | 145 | |
dc.citation.other | 45(3): 140-145 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000244876700005 | |
dc.identifier.doi | 10.1093/chromsci/45.3.140 | |
dc.identifier.pmid | 17462128 | |
dc.identifier.scopus | 2-s2.0-33947142405 | |
dc.type.version | publishedVersion |