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dc.creatorPešić, V.
dc.creatorRadojević, Katarina
dc.creatorKosec, Duško
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorPerišić, M.
dc.creatorPilipović, Ivan
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:11:13Z
dc.date.available2019-09-02T11:11:13Z
dc.date.issued2007
dc.identifier.issn0100-879X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/987
dc.description.abstractThe role of gonadal hormones in induction and, particularly, maintenance/ progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on thymic weight and morphometric parameters at different times up to the age of 10 months. Up to 6 months post-castration both thymic weight and cellularity in orchidectomized ( Cx) rats were greater than in age-matched control rats, sham Cx ( Sx). The increase in thymic cellularity reflected an increase in thymocyte proliferation rate ( the proportion of proliferating cells was 18.6 +/- 0.7% in 2-month-old Cx ( N = 5) vs 13.4 +/- 0.3% ( N = 5) in age-matched Sx rats) followed by reduced sensitivity to apoptotic signals ( apoptotic thymocytes were 9.8 +/- 0.9% in 2-month-old Cx ( N = 5) vs 15.5 +/- 0.3% ( N = 5) age-matched Sx rats). However, 9 months post-orchidectomy, neither thymic weight and cellularity nor any of the morphometric parameters analyzed differed between Cx and control rats. The reduction of thymic cellularity in Cx rats to control values may be related to increased sensitivity of their thymocytes to apoptotic signals in culture ( 72.6 +/- 1.2% in 10-month-old vs 9.8 +/- 0.9% in 2-month-old Cx rats) followed by reduced responsiveness to proliferative stimuli ( 14.1 +/- 0.2% in 10-month-old vs 18.6 +/- 0.7% in 2-month-old Cx rats). Thus, the study indicates that the effects of peripubertal orchidectomy on thymic weight and cellularity, as well as on the main morphometric indices, are long-lasting but not permanent, i.e., that removal of the testes can only postpone but not prevent age-related organ atrophy and consequently functional deterioration of the immune system.en
dc.publisherAssoc Bras Divulg Cientifica, Sao Paulo
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145049/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceBrazilian Journal of Medical and Biological Research
dc.subjectrat thymusen
dc.subjectagingen
dc.subjectorchidectomyen
dc.subjectstereological analysisen
dc.subjectthymocyte proliferationen
dc.subjectthymocyte apoptosisen
dc.titlePeripubertal orchidectomy transitorily affects age-associated thymic involution in ratsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЛепосавић, Гордана; Радојевић, Катарина; Косец, Душко; Плећаш-Соларовић, Босиљка; Перишић, М.; Пилиповић, Иван; Пешић, В.;
dc.citation.volume40
dc.citation.issue11
dc.citation.spage1481
dc.citation.epage1493
dc.citation.other40(11): 1481-1493
dc.citation.rankM22
dc.identifier.wos000250175400009
dc.identifier.doi10.1590/S0100-879X2006005000172
dc.identifier.pmid17934645
dc.identifier.scopus2-s2.0-37349035352
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/2312/985.pdf
dc.type.versionpublishedVersion


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