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Optimization of chromatographic separation of aripiprazole and impurities: Quantitative structure-retention relationship approach / Оптимизација хроматографског раздвајања арипипразола и нечистоћа: приступ квантификовања односа структуре и ретенционог понашања
(Serbian Chemical Society, 2022)
A new optimization strategy based on the mixed quantitative struc- ture–retention relationship (QSRR) model is proposed for improving the RP- HPLC separation of aripiprazole and its impurities (IMP A-E). Firstly, experi- ...
Chemical characterization and antimicrobial activity of Juglans nigra L. nut and green husk / Хемијска карактеризација и антимикробна активност орашастог плода и зелене љуске Juglans nigra L.
(Serbian Chemical Society, 2023)
Juglans nigra (Black walnut) is a source of health-supporting biologically active compounds used in traditional medicine. The investigation of bioactive compounds in black walnut could lead to its broader application, as ...
Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy / Деградација протеина индукована PROTAC молекулима као нова стратегија у развоју лекова
(Serbian Chemical Society, 2022)
The traditional concept of drug discovery is based on the occupancydriven pharmacology model. It implies the development of inhibitors occupying binding sites that directly affect protein functions. Therefore, proteins ...
In vitro study of redox properties of azolyl-lactones in human serum / In vitro студија редокс особина азолил-лактона у хуманом серуму
(Serbian Chemical Society, 2023)
Disruption of the redox balance in the body causes oxidative stress that can initiate many diseases. While antioxidants reduce the level of oxidiz- ing compounds in the medium, prooxidants promote the opposite process and ...
Synthesis and biological profiling of novel isocoumarin derivatives and related compounds / СИНТЕЗА И БИОЛОШКО ПРОФИЛИСАЊЕ НОВИХ ИЗОКУМАРИНСКИХ ДЕРИВАТА И СЛИЧНИХ ЈЕДИЊЕЊА
(Serbian Chemical Society, 2021)
In the continuation of our study of substituted isocoumarins a series of novel 3-azolyl isocoumarin and their thio derivatives, including some related lactone compounds was prepared and biologically profiled against C. ...
Application of liquid chromatography in defining the interaction of newly synthesized chalcones and related compounds with human serum albumin / Примена течне хроматографије у дефинисању интеракција новосинтетисаних халкона и сродних супстанци са хуманим серумским албуминима
(Srpsko hemijsko društvo, Beograd, 2023)
Defining the interaction of newly synthesized compounds with plasma proteins is an important step in the drug development process. Chromatographic techniques can be successfully used in predicting the biopharmaceutical ...