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Приказ резултата 11-20 од 55
Application of gastrointestinal simulation for development of in vitro-in vivo correlation for levothyroxine sodium immediate-release tablets
(Elsevier Science BV, Amsterdam, 2011)
Coupled in silico platform: Computational fluid dynamics (CFD) and physiologically-based pharmacokinetic (PBPK) modelling
(Elsevier Science BV, Amsterdam, 2018)
One of the critical components of the respiratory drug delivery is the manner in which the inhaled aerosol is deposited in respiratory tract compartments. Depending on formulation properties, device characteristics and ...
Predicting in vivo behavior of sustained release matrix tablet formulation: numerical convolution versus artificial neural network analysis
(Elsevier Science BV, Amsterdam, 2005)
An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation
(Elsevier Science BV, Amsterdam, 2007)
There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline ...
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats
(Elsevier Science BV, Amsterdam, 2016)
The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated ...
Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery
(Elsevier B.V., 2021)
The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic ...
Comparative efficacy evaluation of different penetration enhancement strategies for dermal delivery of poorly soluble drugs – A case with sertaconazole nitrate
(Elsevier B.V., 2021)
The aim of this study was to compare the efficacy of different approaches for enhancement of dermal availability of the highly lipophilic antifungal model drug – sertaconazole nitrate (SN). For this purpose, a physical ...
Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review
(Elsevier, 2020)
The release and absorption profile of an oral medication is influenced by the physicochemical properties of the drug and its formulation, as well as by the anatomy and physiology of the gastrointestinal (GI) tract. During ...
Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets
(Elsevier B.V., 2020)
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. ...
Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs
(Elsevier Science BV, Amsterdam, 2016)
Tocopherols and tocotrienols belong to the family of vitamin E (VE) with the well-known antioxidant properties. For certain alpha-tocopherol and gamma-tocotrienol derivatives used as the lead compounds in this study, ...