Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans
2008
Аутори
Žarković, MilošIgnjatović, Svetlana
Dajak, Marijana
Ćirić, Jasmina
Beleslin, Biljana
Savić, Slavica
Stojković, Mirjana
Bulat, Petar
Trbojević, Bozo
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly wi...th cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.
Извор:
European Journal of Endocrinology, 2008, 159, 5, 649-652Издавач:
- Bioscientifica Ltd, Bristol
Финансирање / пројекти:
DOI: 10.1530/EJE-08-0544
ISSN: 0804-4643
PubMed: 18753312
WoS: 000260965600021
Scopus: 2-s2.0-56749092171
Институција/група
PharmacyTY - JOUR AU - Žarković, Miloš AU - Ignjatović, Svetlana AU - Dajak, Marijana AU - Ćirić, Jasmina AU - Beleslin, Biljana AU - Savić, Slavica AU - Stojković, Mirjana AU - Bulat, Petar AU - Trbojević, Bozo PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1026 AB - Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions. PB - Bioscientifica Ltd, Bristol T2 - European Journal of Endocrinology T1 - Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans VL - 159 IS - 5 SP - 649 EP - 652 DO - 10.1530/EJE-08-0544 ER -
@article{ author = "Žarković, Miloš and Ignjatović, Svetlana and Dajak, Marijana and Ćirić, Jasmina and Beleslin, Biljana and Savić, Slavica and Stojković, Mirjana and Bulat, Petar and Trbojević, Bozo", year = "2008", abstract = "Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.", publisher = "Bioscientifica Ltd, Bristol", journal = "European Journal of Endocrinology", title = "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans", volume = "159", number = "5", pages = "649-652", doi = "10.1530/EJE-08-0544" }
Žarković, M., Ignjatović, S., Dajak, M., Ćirić, J., Beleslin, B., Savić, S., Stojković, M., Bulat, P.,& Trbojević, B.. (2008). Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology Bioscientifica Ltd, Bristol., 159(5), 649-652. https://doi.org/10.1530/EJE-08-0544
Žarković M, Ignjatović S, Dajak M, Ćirić J, Beleslin B, Savić S, Stojković M, Bulat P, Trbojević B. Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology. 2008;159(5):649-652. doi:10.1530/EJE-08-0544 .
Žarković, Miloš, Ignjatović, Svetlana, Dajak, Marijana, Ćirić, Jasmina, Beleslin, Biljana, Savić, Slavica, Stojković, Mirjana, Bulat, Petar, Trbojević, Bozo, "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans" in European Journal of Endocrinology, 159, no. 5 (2008):649-652, https://doi.org/10.1530/EJE-08-0544 . .