Prikaz osnovnih podataka o dokumentu
A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol
dc.creator | Gojković-Bukarica, Ljiljana | |
dc.creator | Novaković, Aleksandra | |
dc.creator | Kanjuh, Vladimir | |
dc.creator | Bumbasirević, Marko | |
dc.creator | Lesić, Aleksandar | |
dc.creator | Heinle, Helmut | |
dc.date.accessioned | 2019-09-02T11:12:38Z | |
dc.date.available | 2019-09-02T11:12:38Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1347-8613 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1041 | |
dc.description.abstract | Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced con centration-dependent relaxation of rat mesenteric artery. Among the K+-channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibendamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K+, the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence of K+ channels and voltage-gated Ca2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 in M K- in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K+ channels. Its ability to completely relax the mesenteric artery precontracted with K+-rich solution suggests that K channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K+ channel-independent effect of resveratrol. | en |
dc.publisher | Japanese Pharmacological Soc, Kyoto | |
dc.relation | Ministry of Science and Technology (Serbia) | |
dc.relation | Karl & Lora Klein Foundation (Germany) | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Pharmacological Sciences | |
dc.subject | resveratrol | en |
dc.subject | rat mesenteric artery | en |
dc.subject | ion channel | en |
dc.subject | vasorelaxation | en |
dc.subject | K+ channel | en |
dc.title | A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Хеинле, Хелмут; Новаковић, Aлександра; Гојковић-Букарица, Љиљана; Лесић, Aлександар; Бумбасиревић, Марко; Кањух, Владимир; | |
dc.citation.volume | 108 | |
dc.citation.issue | 1 | |
dc.citation.spage | 124 | |
dc.citation.epage | 130 | |
dc.citation.other | 108(1): 124-130 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000259683400015 | |
dc.identifier.doi | 10.1254/jphs.08128FP | |
dc.identifier.pmid | 18818483 | |
dc.identifier.scopus | 2-s2.0-52949145570 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/34/1039.pdf | |
dc.type.version | publishedVersion |