Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines
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2008
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The present review summarizes recent data on age-related thymic changes termed thymic involution, and highlights the putative role of perturbances in extrathymical and, possibly, intrathymical production of gonadal steroids and catecholamines in this process. Thymic involution has been envisaged as an extremely complex process involving multifactorial mechanisms along the bone marrow-thymic axis that accounts for the major manifestations of immunosenescence. These mechanisms include basic cell aging processes (for example, cell replication and programmed cell death) and processes unique to the immune system (such as generation of the T cell receptor repertoire and control of potentially autoreactive cells). Given that the onset of age-associated thymic involution coincides with the rise in gonadal steroid levels at puberty, a causal link between these events has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenalin...e in adult male and female thymus and (2) catecholamines, acting via alpha- and beta-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both effector and regulatory T cells. Furthermore, the possibility that gonadal steroids contribute to thymic involution is discussed in this paper. In light of recent data indicating that effects of gonadal hormone deprivation on the thymic cellularity and function are long lasting but transitory, a putative role for the intrathymic sex steroid/catecholamine production in assuring the organ involution, under conditions of their limited supply by extrathymic sources, is also considered. Copyright
Ključne reči:
Thymus / Involution / Thymopoiesis / Sex steroids / CatecholaminesIzvor:
NeuroImmunoModulation, 2008, 15, 4-6, 290-322Izdavač:
- Karger, Basel
Finansiranje / projekti:
- Neuroendokrina modulacija imunskog odgovora: uloga simpato-adrenomedularnog sistema (RS-MESTD-MPN2006-2010-145049)
DOI: 10.1159/000156473
ISSN: 1021-7401
PubMed: 19047807
WoS: 000261564000010
Scopus: 2-s2.0-57149085680
Institucija/grupa
PharmacyTY - JOUR AU - Leposavić, Gordana AU - Perišić, Milica PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1051 AB - The present review summarizes recent data on age-related thymic changes termed thymic involution, and highlights the putative role of perturbances in extrathymical and, possibly, intrathymical production of gonadal steroids and catecholamines in this process. Thymic involution has been envisaged as an extremely complex process involving multifactorial mechanisms along the bone marrow-thymic axis that accounts for the major manifestations of immunosenescence. These mechanisms include basic cell aging processes (for example, cell replication and programmed cell death) and processes unique to the immune system (such as generation of the T cell receptor repertoire and control of potentially autoreactive cells). Given that the onset of age-associated thymic involution coincides with the rise in gonadal steroid levels at puberty, a causal link between these events has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenaline in adult male and female thymus and (2) catecholamines, acting via alpha- and beta-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both effector and regulatory T cells. Furthermore, the possibility that gonadal steroids contribute to thymic involution is discussed in this paper. In light of recent data indicating that effects of gonadal hormone deprivation on the thymic cellularity and function are long lasting but transitory, a putative role for the intrathymic sex steroid/catecholamine production in assuring the organ involution, under conditions of their limited supply by extrathymic sources, is also considered. Copyright PB - Karger, Basel T2 - NeuroImmunoModulation T1 - Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines VL - 15 IS - 4-6 SP - 290 EP - 322 DO - 10.1159/000156473 ER -
@article{ author = "Leposavić, Gordana and Perišić, Milica", year = "2008", abstract = "The present review summarizes recent data on age-related thymic changes termed thymic involution, and highlights the putative role of perturbances in extrathymical and, possibly, intrathymical production of gonadal steroids and catecholamines in this process. Thymic involution has been envisaged as an extremely complex process involving multifactorial mechanisms along the bone marrow-thymic axis that accounts for the major manifestations of immunosenescence. These mechanisms include basic cell aging processes (for example, cell replication and programmed cell death) and processes unique to the immune system (such as generation of the T cell receptor repertoire and control of potentially autoreactive cells). Given that the onset of age-associated thymic involution coincides with the rise in gonadal steroid levels at puberty, a causal link between these events has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenaline in adult male and female thymus and (2) catecholamines, acting via alpha- and beta-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both effector and regulatory T cells. Furthermore, the possibility that gonadal steroids contribute to thymic involution is discussed in this paper. In light of recent data indicating that effects of gonadal hormone deprivation on the thymic cellularity and function are long lasting but transitory, a putative role for the intrathymic sex steroid/catecholamine production in assuring the organ involution, under conditions of their limited supply by extrathymic sources, is also considered. Copyright", publisher = "Karger, Basel", journal = "NeuroImmunoModulation", title = "Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines", volume = "15", number = "4-6", pages = "290-322", doi = "10.1159/000156473" }
Leposavić, G.,& Perišić, M.. (2008). Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines. in NeuroImmunoModulation Karger, Basel., 15(4-6), 290-322. https://doi.org/10.1159/000156473
Leposavić G, Perišić M. Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines. in NeuroImmunoModulation. 2008;15(4-6):290-322. doi:10.1159/000156473 .
Leposavić, Gordana, Perišić, Milica, "Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines" in NeuroImmunoModulation, 15, no. 4-6 (2008):290-322, https://doi.org/10.1159/000156473 . .