Oxidative stress in rat kidneys due to 3,4-methylenedioxymetamphetamine (ecstasy) toxicity
Samo za registrovane korisnike
2008
Autori
Ninković, MilicaSelaković, Vesna
Đukić, Mirjana
Milosavljević, Petar
Vasiljević, Ivana
Jovanović, Marina
Maličević, Živorad
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Aim: The mechanism of MDMA (3,4-methylenedioxymethamphetamine)-induced toxicity is believed to be, in part, due to enhanced oxidative stress. As MDMA is eliminated via the kidney, the aim. of this study was to investigate whether MDMA created conditions of oxidative stress within rat kidney. Methods: Adult male Wistar rats were divided into three groups, control treatment (water), acute MDMA administration (single oral dose: 5, 10, 20 or 40 mg/kg body weight) and subacute MDMA administration (5, 10, or 20 mg/kg body weight per day during 14 days). Animals were sacrificed 8 h after the single oral MDMA administration in the acute MDMA administration group and after the last MDMA administration in the subacute MDMA administration group. Rectal temperature measurements, oxidative stress status parameters and histological examinations were performed. Results: In all MDMA-administered rats, rectal temperature markedly increased peaking approximately 1 h after MDMA ingestion. Superoxide dism...utase activity and thiobarbituric acid reactive substances increased after MDMA administration. Histological examinations of the kidney revealed dose-dependent disruption of tissue structure in subacute MDMA-administered rats. The latter was not observed in acute MDMA-administered rats.
Ključne reči:
kidney / lipid peroxidation / MDMA / oxidative stressIzvor:
Nephrology, 2008, 13, 1, 33-37Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Biohemijski pokazatelji oštećenja i disfunkcije organa (RS-MESTD-MPN2006-2010-145010)
DOI: 10.1111/j.1440-1797.2007.00886.x
ISSN: 1320-5358
PubMed: 18199099
WoS: 000253425300006
Scopus: 2-s2.0-38149115550
Institucija/grupa
PharmacyTY - JOUR AU - Ninković, Milica AU - Selaković, Vesna AU - Đukić, Mirjana AU - Milosavljević, Petar AU - Vasiljević, Ivana AU - Jovanović, Marina AU - Maličević, Živorad PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1060 AB - Aim: The mechanism of MDMA (3,4-methylenedioxymethamphetamine)-induced toxicity is believed to be, in part, due to enhanced oxidative stress. As MDMA is eliminated via the kidney, the aim. of this study was to investigate whether MDMA created conditions of oxidative stress within rat kidney. Methods: Adult male Wistar rats were divided into three groups, control treatment (water), acute MDMA administration (single oral dose: 5, 10, 20 or 40 mg/kg body weight) and subacute MDMA administration (5, 10, or 20 mg/kg body weight per day during 14 days). Animals were sacrificed 8 h after the single oral MDMA administration in the acute MDMA administration group and after the last MDMA administration in the subacute MDMA administration group. Rectal temperature measurements, oxidative stress status parameters and histological examinations were performed. Results: In all MDMA-administered rats, rectal temperature markedly increased peaking approximately 1 h after MDMA ingestion. Superoxide dismutase activity and thiobarbituric acid reactive substances increased after MDMA administration. Histological examinations of the kidney revealed dose-dependent disruption of tissue structure in subacute MDMA-administered rats. The latter was not observed in acute MDMA-administered rats. PB - Wiley, Hoboken T2 - Nephrology T1 - Oxidative stress in rat kidneys due to 3,4-methylenedioxymetamphetamine (ecstasy) toxicity VL - 13 IS - 1 SP - 33 EP - 37 DO - 10.1111/j.1440-1797.2007.00886.x ER -
@article{ author = "Ninković, Milica and Selaković, Vesna and Đukić, Mirjana and Milosavljević, Petar and Vasiljević, Ivana and Jovanović, Marina and Maličević, Živorad", year = "2008", abstract = "Aim: The mechanism of MDMA (3,4-methylenedioxymethamphetamine)-induced toxicity is believed to be, in part, due to enhanced oxidative stress. As MDMA is eliminated via the kidney, the aim. of this study was to investigate whether MDMA created conditions of oxidative stress within rat kidney. Methods: Adult male Wistar rats were divided into three groups, control treatment (water), acute MDMA administration (single oral dose: 5, 10, 20 or 40 mg/kg body weight) and subacute MDMA administration (5, 10, or 20 mg/kg body weight per day during 14 days). Animals were sacrificed 8 h after the single oral MDMA administration in the acute MDMA administration group and after the last MDMA administration in the subacute MDMA administration group. Rectal temperature measurements, oxidative stress status parameters and histological examinations were performed. Results: In all MDMA-administered rats, rectal temperature markedly increased peaking approximately 1 h after MDMA ingestion. Superoxide dismutase activity and thiobarbituric acid reactive substances increased after MDMA administration. Histological examinations of the kidney revealed dose-dependent disruption of tissue structure in subacute MDMA-administered rats. The latter was not observed in acute MDMA-administered rats.", publisher = "Wiley, Hoboken", journal = "Nephrology", title = "Oxidative stress in rat kidneys due to 3,4-methylenedioxymetamphetamine (ecstasy) toxicity", volume = "13", number = "1", pages = "33-37", doi = "10.1111/j.1440-1797.2007.00886.x" }
Ninković, M., Selaković, V., Đukić, M., Milosavljević, P., Vasiljević, I., Jovanović, M.,& Maličević, Ž.. (2008). Oxidative stress in rat kidneys due to 3,4-methylenedioxymetamphetamine (ecstasy) toxicity. in Nephrology Wiley, Hoboken., 13(1), 33-37. https://doi.org/10.1111/j.1440-1797.2007.00886.x
Ninković M, Selaković V, Đukić M, Milosavljević P, Vasiljević I, Jovanović M, Maličević Ž. Oxidative stress in rat kidneys due to 3,4-methylenedioxymetamphetamine (ecstasy) toxicity. in Nephrology. 2008;13(1):33-37. doi:10.1111/j.1440-1797.2007.00886.x .
Ninković, Milica, Selaković, Vesna, Đukić, Mirjana, Milosavljević, Petar, Vasiljević, Ivana, Jovanović, Marina, Maličević, Živorad, "Oxidative stress in rat kidneys due to 3,4-methylenedioxymetamphetamine (ecstasy) toxicity" in Nephrology, 13, no. 1 (2008):33-37, https://doi.org/10.1111/j.1440-1797.2007.00886.x . .