alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.
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Аутори
Jelić-Ivanović, ZoranaSpasojević-Kalimanovska, Vesna
Topić, Aleksandra
Spasić, S
Petrović, V
Чланак у часопису (Објављена верзија)
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The distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p lt 0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed.
Извор:
Gene geography : a computerized bulletin on human gene frequencies, 1994, 8, 2, 129-135Институција/група
PharmacyTY - JOUR AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Topić, Aleksandra AU - Spasić, S AU - Petrović, V PY - 1994 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/113 AB - The distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p lt 0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed. T2 - Gene geography : a computerized bulletin on human gene frequencies T1 - alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium. VL - 8 IS - 2 SP - 129 EP - 135 UR - https://hdl.handle.net/21.15107/rcub_farfar_113 ER -
@article{ author = "Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Topić, Aleksandra and Spasić, S and Petrović, V", year = "1994", abstract = "The distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p lt 0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed.", journal = "Gene geography : a computerized bulletin on human gene frequencies", title = "alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.", volume = "8", number = "2", pages = "129-135", url = "https://hdl.handle.net/21.15107/rcub_farfar_113" }
Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Topić, A., Spasić, S.,& Petrović, V.. (1994). alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.. in Gene geography : a computerized bulletin on human gene frequencies, 8(2), 129-135. https://hdl.handle.net/21.15107/rcub_farfar_113
Jelić-Ivanović Z, Spasojević-Kalimanovska V, Topić A, Spasić S, Petrović V. alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.. in Gene geography : a computerized bulletin on human gene frequencies. 1994;8(2):129-135. https://hdl.handle.net/21.15107/rcub_farfar_113 .
Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Topić, Aleksandra, Spasić, S, Petrović, V, "alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium." in Gene geography : a computerized bulletin on human gene frequencies, 8, no. 2 (1994):129-135, https://hdl.handle.net/21.15107/rcub_farfar_113 .