Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices
Samo za registrovane korisnike
2009
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes ...in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.
Ključne reči:
controlled release / diffusion / mathematical modelling / polyethylene oxide (PEO) matrix / swellingIzvor:
Journal of Pharmacy and Pharmacology, 2009, 61, 11, 1449-1456Izdavač:
- Wiley-Blackwell Publishing, Inc, Malden
Finansiranje / projekti:
DOI: 10.1211/jpp/61.11.0003
ISSN: 0022-3573
PubMed: 19903369
WoS: 000281136600003
Scopus: 2-s2.0-75749118969
Institucija/grupa
PharmacyTY - JOUR AU - Petrović, Jelena AU - Jocković, Jelena AU - Ibrić, Svetlana AU - Đurić, Zorica PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1193 AB - Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing. PB - Wiley-Blackwell Publishing, Inc, Malden T2 - Journal of Pharmacy and Pharmacology T1 - Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices VL - 61 IS - 11 SP - 1449 EP - 1456 DO - 10.1211/jpp/61.11.0003 ER -
@article{ author = "Petrović, Jelena and Jocković, Jelena and Ibrić, Svetlana and Đurić, Zorica", year = "2009", abstract = "Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.", publisher = "Wiley-Blackwell Publishing, Inc, Malden", journal = "Journal of Pharmacy and Pharmacology", title = "Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices", volume = "61", number = "11", pages = "1449-1456", doi = "10.1211/jpp/61.11.0003" }
Petrović, J., Jocković, J., Ibrić, S.,& Đurić, Z.. (2009). Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. in Journal of Pharmacy and Pharmacology Wiley-Blackwell Publishing, Inc, Malden., 61(11), 1449-1456. https://doi.org/10.1211/jpp/61.11.0003
Petrović J, Jocković J, Ibrić S, Đurić Z. Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. in Journal of Pharmacy and Pharmacology. 2009;61(11):1449-1456. doi:10.1211/jpp/61.11.0003 .
Petrović, Jelena, Jocković, Jelena, Ibrić, Svetlana, Đurić, Zorica, "Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices" in Journal of Pharmacy and Pharmacology, 61, no. 11 (2009):1449-1456, https://doi.org/10.1211/jpp/61.11.0003 . .