Atherogenic dyslipidemia and oxidative stress: a new look
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2009
Authors
Rizzo, ManfrediKotur-Stevuljević, Jelena
Berneis, Kaspar
Spinas, Giatgen
Rini, Giovam Battista
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Vekić, Jelena
Article (Published version)
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Show full item recordAbstract
Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)
Source:
Transplant International, 2009, 153, 5, 217-223Publisher:
- Elsevier Science Inc, New York
Funding / projects:
- Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-MESTD-MPN2006-2010-145036)
DOI: 10.1016/j.trsl.2009.01.008
ISSN: 1931-5244
PubMed: 19375682
WoS: 000265756600002
Scopus: 2-s2.0-64349105661
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Institution/Community
PharmacyTY - JOUR AU - Rizzo, Manfredi AU - Kotur-Stevuljević, Jelena AU - Berneis, Kaspar AU - Spinas, Giatgen AU - Rini, Giovam Battista AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Vekić, Jelena PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1228 AB - Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223) PB - Elsevier Science Inc, New York T2 - Transplant International T1 - Atherogenic dyslipidemia and oxidative stress: a new look VL - 153 IS - 5 SP - 217 EP - 223 DO - 10.1016/j.trsl.2009.01.008 ER -
@article{ author = "Rizzo, Manfredi and Kotur-Stevuljević, Jelena and Berneis, Kaspar and Spinas, Giatgen and Rini, Giovam Battista and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Vekić, Jelena", year = "2009", abstract = "Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)", publisher = "Elsevier Science Inc, New York", journal = "Transplant International", title = "Atherogenic dyslipidemia and oxidative stress: a new look", volume = "153", number = "5", pages = "217-223", doi = "10.1016/j.trsl.2009.01.008" }
Rizzo, M., Kotur-Stevuljević, J., Berneis, K., Spinas, G., Rini, G. B., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Vekić, J.. (2009). Atherogenic dyslipidemia and oxidative stress: a new look. in Transplant International Elsevier Science Inc, New York., 153(5), 217-223. https://doi.org/10.1016/j.trsl.2009.01.008
Rizzo M, Kotur-Stevuljević J, Berneis K, Spinas G, Rini GB, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Vekić J. Atherogenic dyslipidemia and oxidative stress: a new look. in Transplant International. 2009;153(5):217-223. doi:10.1016/j.trsl.2009.01.008 .
Rizzo, Manfredi, Kotur-Stevuljević, Jelena, Berneis, Kaspar, Spinas, Giatgen, Rini, Giovam Battista, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, "Atherogenic dyslipidemia and oxidative stress: a new look" in Transplant International, 153, no. 5 (2009):217-223, https://doi.org/10.1016/j.trsl.2009.01.008 . .