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Study of protolytic, hydrolytic and solubility equilibria of midazolam
dc.creator | Pfendt, Lidija | |
dc.creator | Janjić, T.J | |
dc.creator | Popović, Gordana | |
dc.date.accessioned | 2019-09-02T10:49:04Z | |
dc.date.available | 2019-09-02T10:49:04Z | |
dc.date.issued | 1995 | |
dc.identifier.issn | 0003-2654 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/123 | |
dc.description.abstract | Protolytic equilibria of midazolam in the pH range 0-12 were investigated. Acidity, hydrolysis, equilibrium constants in the heterogeneous system and the solubility of midazolam were determined [I = 0.1 mol l-1 (NaCl), 25 °C]. A spectrophotometric method was developed for the investigation of the mechanism of hydrolysis and the determination of the corresponding equilibrium constants. In addition, buffer characteristics of the two-phase and single-phase midazolam buffers were investigated. | en |
dc.rights | restrictedAccess | |
dc.source | The Analyst | |
dc.subject | Heterogeneous equilibria | en |
dc.subject | Hydrolysis | en |
dc.subject | Midazolam | en |
dc.subject | Protolytic equilibria | en |
dc.subject | Single- and two-phase buffer | en |
dc.title | Study of protolytic, hydrolytic and solubility equilibria of midazolam | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Пфендт, Лидија; Јањић, Т.Ј; Поповић, Гордана; | |
dc.citation.volume | 120 | |
dc.citation.issue | 8 | |
dc.citation.spage | 2145 | |
dc.citation.epage | 2151 | |
dc.citation.other | 120(8): 2145-2151 | |
dc.identifier.doi | 10.1039/AN9952002145 | |
dc.identifier.scopus | 2-s2.0-0029149896 | |
dc.type.version | publishedVersion |