Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles
Само за регистроване кориснике
2009
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: The potential for use of chitosan-treated alginate microparticles as a vehicle for oral phenytoin delivery has not been thoroughly exploited. Aim: We studied the influence of preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. Method: The total number of 24 microparticles formulations prepared by varying contents of calcium gelling ions and varying contents and type of chitosan was examined. As an additional variable, two different hardening times (1 and 24 hours) were employed. Possible interactions of components, surface morphology of microparticles as well as release profile of phenytoin were studied. Results: Both series of formulations with regard to hardening times, irrespective of the chitosan type and/or concentration employed appeared to be highly loaded with the model drug (above 90%). The drug release studies showed that the kinetics of phenytoin cannot be straightforwardly predicted base...d on the molecular weight of chitosan alone. On the other hand, prolonging the hardening time from 1 to 24 hours had significantly improved phenytoin kinetics, and gave rise to a formulation with the liberation half-time of about 2.5 hours. Conclusion: This study showed that the latter formulation is eligible for further modifications aimed at improving the regularity of phenytoin absorption.
Кључне речи:
Alginate-chitosan microparticles / phenytoin / physicochemical characterization / preparation / release behaviorИзвор:
Drug Development and Industrial Pharmacy, 2009, 35, 9, 1092-1102Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-MPN2006-2010-142063)
DOI: 10.1080/03639040902774164
ISSN: 0363-9045
PubMed: 19365778
WoS: 000269927100009
Scopus: 2-s2.0-70350672557
Институција/група
PharmacyTY - JOUR AU - Cekić, Nebojša AU - Milić, Jela AU - Savić, Snežana AU - Savić, Miroslav AU - Jović, Žarko AU - Daniels, Rolf PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1261 AB - Background: The potential for use of chitosan-treated alginate microparticles as a vehicle for oral phenytoin delivery has not been thoroughly exploited. Aim: We studied the influence of preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. Method: The total number of 24 microparticles formulations prepared by varying contents of calcium gelling ions and varying contents and type of chitosan was examined. As an additional variable, two different hardening times (1 and 24 hours) were employed. Possible interactions of components, surface morphology of microparticles as well as release profile of phenytoin were studied. Results: Both series of formulations with regard to hardening times, irrespective of the chitosan type and/or concentration employed appeared to be highly loaded with the model drug (above 90%). The drug release studies showed that the kinetics of phenytoin cannot be straightforwardly predicted based on the molecular weight of chitosan alone. On the other hand, prolonging the hardening time from 1 to 24 hours had significantly improved phenytoin kinetics, and gave rise to a formulation with the liberation half-time of about 2.5 hours. Conclusion: This study showed that the latter formulation is eligible for further modifications aimed at improving the regularity of phenytoin absorption. PB - Taylor & Francis Ltd, Abingdon T2 - Drug Development and Industrial Pharmacy T1 - Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles VL - 35 IS - 9 SP - 1092 EP - 1102 DO - 10.1080/03639040902774164 ER -
@article{ author = "Cekić, Nebojša and Milić, Jela and Savić, Snežana and Savić, Miroslav and Jović, Žarko and Daniels, Rolf", year = "2009", abstract = "Background: The potential for use of chitosan-treated alginate microparticles as a vehicle for oral phenytoin delivery has not been thoroughly exploited. Aim: We studied the influence of preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. Method: The total number of 24 microparticles formulations prepared by varying contents of calcium gelling ions and varying contents and type of chitosan was examined. As an additional variable, two different hardening times (1 and 24 hours) were employed. Possible interactions of components, surface morphology of microparticles as well as release profile of phenytoin were studied. Results: Both series of formulations with regard to hardening times, irrespective of the chitosan type and/or concentration employed appeared to be highly loaded with the model drug (above 90%). The drug release studies showed that the kinetics of phenytoin cannot be straightforwardly predicted based on the molecular weight of chitosan alone. On the other hand, prolonging the hardening time from 1 to 24 hours had significantly improved phenytoin kinetics, and gave rise to a formulation with the liberation half-time of about 2.5 hours. Conclusion: This study showed that the latter formulation is eligible for further modifications aimed at improving the regularity of phenytoin absorption.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Drug Development and Industrial Pharmacy", title = "Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles", volume = "35", number = "9", pages = "1092-1102", doi = "10.1080/03639040902774164" }
Cekić, N., Milić, J., Savić, S., Savić, M., Jović, Ž.,& Daniels, R.. (2009). Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. in Drug Development and Industrial Pharmacy Taylor & Francis Ltd, Abingdon., 35(9), 1092-1102. https://doi.org/10.1080/03639040902774164
Cekić N, Milić J, Savić S, Savić M, Jović Ž, Daniels R. Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles. in Drug Development and Industrial Pharmacy. 2009;35(9):1092-1102. doi:10.1080/03639040902774164 .
Cekić, Nebojša, Milić, Jela, Savić, Snežana, Savić, Miroslav, Jović, Žarko, Daniels, Rolf, "Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate-chitosan microparticles" in Drug Development and Industrial Pharmacy, 35, no. 9 (2009):1092-1102, https://doi.org/10.1080/03639040902774164 . .