Certain rheologycal behaviour of paracetamol solid dispersion powders
Апстракт
Paracetamol powder (PAR) has poor compressibility, high cohesivity and is difficult to compress. We have prepared dispersions of PAR and 3-cyclodextrin (β-CD) in physical mixture form, kneaded solid dispersion and spray dried solid dispersion (the ratio 1:1 w/w), and spray dried solid dispersion of PAR-Ethocel-Macogol 6000 (95:2:3), as well. The Theological characteristics of this dispersions were observed. The crystalline structure, size and shape of PAR dispersion powders differed from PAR alone. Consequently, they showed improvement in packing density; reductions in cohesivity (Kawakita's cohesivity constant was the lowest with kneaded solid dispersion PAR-β-CD); good flowability and angle of repose (especially with kneded solid dispersion PAR-β-CD). We also examined the rheological behaviour of tablet formulations prepared from those dispersions and found some correlation between the weight variation of tablets and the mixture flow properties.
Кључне речи:
Paracetamol / Powder rheology / Solid dispersion / β-cyclodextrinИзвор:
Bollettino chimico farmaceutico, 1996, 135, 7, 401-408Издавач:
- Lubner Communication Srl
Институција/група
PharmacyTY - JOUR AU - Tasić, Ljiljana AU - Pintye-Hódi, K PY - 1996 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/131 AB - Paracetamol powder (PAR) has poor compressibility, high cohesivity and is difficult to compress. We have prepared dispersions of PAR and 3-cyclodextrin (β-CD) in physical mixture form, kneaded solid dispersion and spray dried solid dispersion (the ratio 1:1 w/w), and spray dried solid dispersion of PAR-Ethocel-Macogol 6000 (95:2:3), as well. The Theological characteristics of this dispersions were observed. The crystalline structure, size and shape of PAR dispersion powders differed from PAR alone. Consequently, they showed improvement in packing density; reductions in cohesivity (Kawakita's cohesivity constant was the lowest with kneaded solid dispersion PAR-β-CD); good flowability and angle of repose (especially with kneded solid dispersion PAR-β-CD). We also examined the rheological behaviour of tablet formulations prepared from those dispersions and found some correlation between the weight variation of tablets and the mixture flow properties. PB - Lubner Communication Srl T2 - Bollettino chimico farmaceutico T1 - Certain rheologycal behaviour of paracetamol solid dispersion powders VL - 135 IS - 7 SP - 401 EP - 408 UR - https://hdl.handle.net/21.15107/rcub_farfar_131 ER -
@article{ author = "Tasić, Ljiljana and Pintye-Hódi, K", year = "1996", abstract = "Paracetamol powder (PAR) has poor compressibility, high cohesivity and is difficult to compress. We have prepared dispersions of PAR and 3-cyclodextrin (β-CD) in physical mixture form, kneaded solid dispersion and spray dried solid dispersion (the ratio 1:1 w/w), and spray dried solid dispersion of PAR-Ethocel-Macogol 6000 (95:2:3), as well. The Theological characteristics of this dispersions were observed. The crystalline structure, size and shape of PAR dispersion powders differed from PAR alone. Consequently, they showed improvement in packing density; reductions in cohesivity (Kawakita's cohesivity constant was the lowest with kneaded solid dispersion PAR-β-CD); good flowability and angle of repose (especially with kneded solid dispersion PAR-β-CD). We also examined the rheological behaviour of tablet formulations prepared from those dispersions and found some correlation between the weight variation of tablets and the mixture flow properties.", publisher = "Lubner Communication Srl", journal = "Bollettino chimico farmaceutico", title = "Certain rheologycal behaviour of paracetamol solid dispersion powders", volume = "135", number = "7", pages = "401-408", url = "https://hdl.handle.net/21.15107/rcub_farfar_131" }
Tasić, L.,& Pintye-Hódi, K.. (1996). Certain rheologycal behaviour of paracetamol solid dispersion powders. in Bollettino chimico farmaceutico Lubner Communication Srl., 135(7), 401-408. https://hdl.handle.net/21.15107/rcub_farfar_131
Tasić L, Pintye-Hódi K. Certain rheologycal behaviour of paracetamol solid dispersion powders. in Bollettino chimico farmaceutico. 1996;135(7):401-408. https://hdl.handle.net/21.15107/rcub_farfar_131 .
Tasić, Ljiljana, Pintye-Hódi, K, "Certain rheologycal behaviour of paracetamol solid dispersion powders" in Bollettino chimico farmaceutico, 135, no. 7 (1996):401-408, https://hdl.handle.net/21.15107/rcub_farfar_131 .