GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products
Abstract
A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.
Keywords:
Gas chromatography-electron capture detection / Pharmaceutical products / Shampoo, gel and emulsion / LindaneSource:
Chromatographia, 2010, 72, 5-6, 581-584Publisher:
- Springer Heidelberg, Heidelberg
Funding / projects:
DOI: 10.1365/s10337-010-1684-9
ISSN: 0009-5893
WoS: 000281174300029
Scopus: 2-s2.0-77957018484
Collections
Institution/Community
PharmacyTY - JOUR AU - Vujić, Zorica AU - Matić, Silvana AU - Kuntić, Vesna AU - Vladimirov, Sote AU - Uskoković-Marković, Snežana PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1339 AB - A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH. PB - Springer Heidelberg, Heidelberg T2 - Chromatographia T1 - GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products VL - 72 IS - 5-6 SP - 581 EP - 584 DO - 10.1365/s10337-010-1684-9 ER -
@article{ author = "Vujić, Zorica and Matić, Silvana and Kuntić, Vesna and Vladimirov, Sote and Uskoković-Marković, Snežana", year = "2010", abstract = "A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from alpha-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5-15.0 mu g mL(-1) for lindane and 0.005-0.15 mu g mL(-1) for alpha-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 mu g mL(-1) for lindane and 0.005 and 0.002 mu g mL(-1) for alpha-HCH.", publisher = "Springer Heidelberg, Heidelberg", journal = "Chromatographia", title = "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products", volume = "72", number = "5-6", pages = "581-584", doi = "10.1365/s10337-010-1684-9" }
Vujić, Z., Matić, S., Kuntić, V., Vladimirov, S.,& Uskoković-Marković, S.. (2010). GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia Springer Heidelberg, Heidelberg., 72(5-6), 581-584. https://doi.org/10.1365/s10337-010-1684-9
Vujić Z, Matić S, Kuntić V, Vladimirov S, Uskoković-Marković S. GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products. in Chromatographia. 2010;72(5-6):581-584. doi:10.1365/s10337-010-1684-9 .
Vujić, Zorica, Matić, Silvana, Kuntić, Vesna, Vladimirov, Sote, Uskoković-Marković, Snežana, "GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products" in Chromatographia, 72, no. 5-6 (2010):581-584, https://doi.org/10.1365/s10337-010-1684-9 . .