Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts
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2010
Authors
Zdunić, GordanaGođevac, Dejan
Milenković, Marina
Šavikin, Katarina
Menković, Nebojša
Petrović, Silvana
Article (Published version)
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Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.
Keywords:
Hypericum richeri Vill. / oil extracts / quercetin / I3,II8-biapigenin / anti-inflammatory activity / gastroprotective activitySource:
Natural Product Communications, 2010, 5, 8, 1215-1218Publisher:
- Natural Products Inc, Westerville
Funding / projects:
DOI: 10.1177/1934578X1000500814
ISSN: 1934-578X
PubMed: 20839622
WoS: 000281074200014
Scopus: 2-s2.0-77956713475
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Institution/Community
PharmacyTY - JOUR AU - Zdunić, Gordana AU - Gođevac, Dejan AU - Milenković, Marina AU - Šavikin, Katarina AU - Menković, Nebojša AU - Petrović, Silvana PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1343 AB - Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent. PB - Natural Products Inc, Westerville T2 - Natural Product Communications T1 - Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts VL - 5 IS - 8 SP - 1215 EP - 1218 DO - 10.1177/1934578X1000500814 UR - https://hdl.handle.net/21.15107/rcub_farfar_1343 ER -
@article{ author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Šavikin, Katarina and Menković, Nebojša and Petrović, Silvana", year = "2010", abstract = "Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.", publisher = "Natural Products Inc, Westerville", journal = "Natural Product Communications", title = "Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts", volume = "5", number = "8", pages = "1215-1218", doi = "10.1177/1934578X1000500814", url = "https://hdl.handle.net/21.15107/rcub_farfar_1343" }
Zdunić, G., Gođevac, D., Milenković, M., Šavikin, K., Menković, N.,& Petrović, S.. (2010). Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts. in Natural Product Communications Natural Products Inc, Westerville., 5(8), 1215-1218. https://doi.org/10.1177/1934578X1000500814 https://hdl.handle.net/21.15107/rcub_farfar_1343
Zdunić G, Gođevac D, Milenković M, Šavikin K, Menković N, Petrović S. Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts. in Natural Product Communications. 2010;5(8):1215-1218. doi:10.1177/1934578X1000500814 https://hdl.handle.net/21.15107/rcub_farfar_1343 .
Zdunić, Gordana, Gođevac, Dejan, Milenković, Marina, Šavikin, Katarina, Menković, Nebojša, Petrović, Silvana, "Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts" in Natural Product Communications, 5, no. 8 (2010):1215-1218, https://doi.org/10.1177/1934578X1000500814 ., https://hdl.handle.net/21.15107/rcub_farfar_1343 .