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Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts
dc.creator | Zdunić, Gordana | |
dc.creator | Gođevac, Dejan | |
dc.creator | Milenković, Marina | |
dc.creator | Šavikin, Katarina | |
dc.creator | Menković, Nebojša | |
dc.creator | Petrović, Silvana | |
dc.date.accessioned | 2019-09-02T11:20:24Z | |
dc.date.available | 2019-09-02T11:20:24Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1343 | |
dc.description.abstract | Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent. | en |
dc.publisher | Natural Products Inc, Westerville | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/20035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Communications | |
dc.subject | Hypericum richeri Vill. | en |
dc.subject | oil extracts | en |
dc.subject | quercetin | en |
dc.subject | I3,II8-biapigenin | en |
dc.subject | anti-inflammatory activity | en |
dc.subject | gastroprotective activity | en |
dc.title | Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Гођевац, Дејан; Петровић, Силвана; Шавикин, Катарина; Миленковић, Марина; Менковић, Небојша; Здунић, Гордана; | |
dc.citation.volume | 5 | |
dc.citation.issue | 8 | |
dc.citation.spage | 1215 | |
dc.citation.epage | 1218 | |
dc.citation.other | 5(8): 1215-1218 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000281074200014 | |
dc.identifier.doi | 10.1177/1934578X1000500814 | |
dc.identifier.pmid | 20839622 | |
dc.identifier.scopus | 2-s2.0-77956713475 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1343 | |
dc.type.version | publishedVersion |