Role of serotonin in development of esophageal and gastric fundal varices
2010
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Članak u časopisu (Objavljena verzija)
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AIM: To determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS: This prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis. RESULTS: The mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 +/- 24.2 nmol/L vs 65.4 +/- 18.7 nmol/L, P lt 0.0001). There was no significant correlation be-tween serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (r(s) = -0.217, P > 0.05). However, the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (r(s) = -0.601, P lt 0.01). CONCLUSION: Free serotonin is significant in pathogenesis of ...portal hypertension especially in development of fundal varices, indicating the clinical value of serotonergic receptor blockers in these patients.
Ključne reči:
Serotonin / Portal hypertension / Esophageal varices / Fundal varices / PlateletsIzvor:
World Journal of Microbiology & Biotechnology, 2010, 16, 48, 6135-6138Izdavač:
- Baishideng Publ Grp Co Ltd, Beijing
Finansiranje / projekti:
- Ministry of Science and Technological Development, Republic of Serbia - 14501B
DOI: 10.3748/wjg.v16.i48.6135
ISSN: 1007-9327
PubMed: 21182230
WoS: 000285733600014
Scopus: 2-s2.0-78650779472
Institucija/grupa
PharmacyTY - JOUR AU - Rudić, Jelena S. AU - Ćulafić, Đorđe AU - Mirković, Duško AU - Jesić, Rada S. AU - Krstić, Miodrag N. PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1365 AB - AIM: To determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS: This prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis. RESULTS: The mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 +/- 24.2 nmol/L vs 65.4 +/- 18.7 nmol/L, P lt 0.0001). There was no significant correlation be-tween serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (r(s) = -0.217, P > 0.05). However, the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (r(s) = -0.601, P lt 0.01). CONCLUSION: Free serotonin is significant in pathogenesis of portal hypertension especially in development of fundal varices, indicating the clinical value of serotonergic receptor blockers in these patients. PB - Baishideng Publ Grp Co Ltd, Beijing T2 - World Journal of Microbiology & Biotechnology T1 - Role of serotonin in development of esophageal and gastric fundal varices VL - 16 IS - 48 SP - 6135 EP - 6138 DO - 10.3748/wjg.v16.i48.6135 ER -
@article{ author = "Rudić, Jelena S. and Ćulafić, Đorđe and Mirković, Duško and Jesić, Rada S. and Krstić, Miodrag N.", year = "2010", abstract = "AIM: To determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS: This prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis. RESULTS: The mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 +/- 24.2 nmol/L vs 65.4 +/- 18.7 nmol/L, P lt 0.0001). There was no significant correlation be-tween serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (r(s) = -0.217, P > 0.05). However, the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (r(s) = -0.601, P lt 0.01). CONCLUSION: Free serotonin is significant in pathogenesis of portal hypertension especially in development of fundal varices, indicating the clinical value of serotonergic receptor blockers in these patients.", publisher = "Baishideng Publ Grp Co Ltd, Beijing", journal = "World Journal of Microbiology & Biotechnology", title = "Role of serotonin in development of esophageal and gastric fundal varices", volume = "16", number = "48", pages = "6135-6138", doi = "10.3748/wjg.v16.i48.6135" }
Rudić, J. S., Ćulafić, Đ., Mirković, D., Jesić, R. S.,& Krstić, M. N.. (2010). Role of serotonin in development of esophageal and gastric fundal varices. in World Journal of Microbiology & Biotechnology Baishideng Publ Grp Co Ltd, Beijing., 16(48), 6135-6138. https://doi.org/10.3748/wjg.v16.i48.6135
Rudić JS, Ćulafić Đ, Mirković D, Jesić RS, Krstić MN. Role of serotonin in development of esophageal and gastric fundal varices. in World Journal of Microbiology & Biotechnology. 2010;16(48):6135-6138. doi:10.3748/wjg.v16.i48.6135 .
Rudić, Jelena S., Ćulafić, Đorđe, Mirković, Duško, Jesić, Rada S., Krstić, Miodrag N., "Role of serotonin in development of esophageal and gastric fundal varices" in World Journal of Microbiology & Biotechnology, 16, no. 48 (2010):6135-6138, https://doi.org/10.3748/wjg.v16.i48.6135 . .