HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients
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2010
Authors
Stefanović, Aleksandra![](/themes/MirageFarFaR/images/orcid.png)
Kotur-Stevuljević, Jelena
![](/themes/MirageFarFaR/images/orcid.png)
Spasić, Slavica
Vekić, Jelena
![](/themes/MirageFarFaR/images/orcid.png)
Zeljković, Aleksandra
![](/themes/MirageFarFaR/images/orcid.png)
Spasojević-Kalimanovska, Vesna
![](/themes/MirageFarFaR/images/orcid.png)
Jelić-Ivanović, Zorana
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Article (Published version)
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Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly ...HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.
Keywords:
Diabetes mellitus type 2 / Oxidative stress / Paraoxonase / HDL 2 particlesSource:
Clinical Biochemistry, 2010, 43, 15, 1230-1235Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-MESTD-MPN2006-2010-145036)
DOI: 10.1016/j.clinbiochem.2010.08.005
ISSN: 0009-9120
PubMed: 20709049
WoS: 000282204400010
Scopus: 2-s2.0-77956719446
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Institution/Community
PharmacyTY - JOUR AU - Stefanović, Aleksandra AU - Kotur-Stevuljević, Jelena AU - Spasić, Slavica AU - Vekić, Jelena AU - Zeljković, Aleksandra AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1367 AB - Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients VL - 43 IS - 15 SP - 1230 EP - 1235 DO - 10.1016/j.clinbiochem.2010.08.005 ER -
@article{ author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasić, Slavica and Vekić, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana", year = "2010", abstract = "Objectives: In this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM). Design and methods: Oxidative stress status parameters (superoxide anion (O-2(-)), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: Patients had significantly higher concentrations of oxidative stress parameter O-2(-)(p lt 0.001) and antioxidative defence, SOD activity (p lt 0.001). Paraoxonase activity was significantly lower in diabetics (p lt 0.001). The PON1(192) phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p lt 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls. Conclusions: The results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients", volume = "43", number = "15", pages = "1230-1235", doi = "10.1016/j.clinbiochem.2010.08.005" }
Stefanović, A., Kotur-Stevuljević, J., Spasić, S., Vekić, J., Zeljković, A., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2010). HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 43(15), 1230-1235. https://doi.org/10.1016/j.clinbiochem.2010.08.005
Stefanović A, Kotur-Stevuljević J, Spasić S, Vekić J, Zeljković A, Spasojević-Kalimanovska V, Jelić-Ivanović Z. HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients. in Clinical Biochemistry. 2010;43(15):1230-1235. doi:10.1016/j.clinbiochem.2010.08.005 .
Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasić, Slavica, Vekić, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "HDL 2 Particles are associated with hyperglycaemia, lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients" in Clinical Biochemistry, 43, no. 15 (2010):1230-1235, https://doi.org/10.1016/j.clinbiochem.2010.08.005 . .