Impact of discounting in pharmacoeconomic modeling. A case study
Abstract
Discounting adjusts future costs and benefits in terms of their present value. The purpose of this study was to present the effect of discounting on Markov model prepared for the evaluation of the different antihypertensive treatments in Serbia. The Markov model consisting of eight states with the cycle length of six months was constructed. Comparator strategies were diuretic, beta blocker; calcium channel blocker and ACE inhibitors. All therapeutic strategies were compared with strategy no intervention". Complications of hypertension (acute myocardial infraction, angina pectoris or stroke alone or in combinations) and total mortality were observed as outcomes. Time horizon of the study was lifetime of the patient or 100 years old, due to assumption that 99% of the cohort would die at that age. Analyses were performed from the third-party payer perspective. Annual discount rate of 5% was applied at all future costs and effects. Undiscounted results showed that patients who started trea...tment with a beta blocker had the highest life expectancy (49.00 QALY) and being the most cost-effective strategy (ICER = (sic)46.63/QALY compared to no intervention). In the case of discounting the highest gain in the QALY had patients who were on beta blocker, 23.7 QALY. After the discounting cost-effective strategies were ACE inhibitor (ICER = (sic)253.08/QALY compared to no intervention) and diuretic (ICER = (sic)262.54/QALY compared to no intervention). The results of the study showed that the discounting could change the choice of cost-effective therapeutic strategy Biotechnol. & Biotechnol. Eq. 2011, 25(3), 2555-2558
Keywords:
Markov model / discounting / antihypertensive medicationSource:
Biotechnology & Biotechnological Equipment, 2011, 25, 3, 2555-2558Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
DOI: 10.5504/BBEQ.2011.0065
ISSN: 1310-2818
WoS: 000294146000023
Scopus: 2-s2.0-80053064130
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Institution/Community
PharmacyTY - JOUR AU - Lakić, Dragana AU - Petrova, Guenka AU - Bogavac-Stanojević, Nataša AU - Jelić-Ivanović, Zorana PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1480 AB - Discounting adjusts future costs and benefits in terms of their present value. The purpose of this study was to present the effect of discounting on Markov model prepared for the evaluation of the different antihypertensive treatments in Serbia. The Markov model consisting of eight states with the cycle length of six months was constructed. Comparator strategies were diuretic, beta blocker; calcium channel blocker and ACE inhibitors. All therapeutic strategies were compared with strategy no intervention". Complications of hypertension (acute myocardial infraction, angina pectoris or stroke alone or in combinations) and total mortality were observed as outcomes. Time horizon of the study was lifetime of the patient or 100 years old, due to assumption that 99% of the cohort would die at that age. Analyses were performed from the third-party payer perspective. Annual discount rate of 5% was applied at all future costs and effects. Undiscounted results showed that patients who started treatment with a beta blocker had the highest life expectancy (49.00 QALY) and being the most cost-effective strategy (ICER = (sic)46.63/QALY compared to no intervention). In the case of discounting the highest gain in the QALY had patients who were on beta blocker, 23.7 QALY. After the discounting cost-effective strategies were ACE inhibitor (ICER = (sic)253.08/QALY compared to no intervention) and diuretic (ICER = (sic)262.54/QALY compared to no intervention). The results of the study showed that the discounting could change the choice of cost-effective therapeutic strategy Biotechnol. & Biotechnol. Eq. 2011, 25(3), 2555-2558 PB - Taylor & Francis Ltd, Abingdon T2 - Biotechnology & Biotechnological Equipment T1 - Impact of discounting in pharmacoeconomic modeling. A case study VL - 25 IS - 3 SP - 2555 EP - 2558 DO - 10.5504/BBEQ.2011.0065 ER -
@article{ author = "Lakić, Dragana and Petrova, Guenka and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana", year = "2011", abstract = "Discounting adjusts future costs and benefits in terms of their present value. The purpose of this study was to present the effect of discounting on Markov model prepared for the evaluation of the different antihypertensive treatments in Serbia. The Markov model consisting of eight states with the cycle length of six months was constructed. Comparator strategies were diuretic, beta blocker; calcium channel blocker and ACE inhibitors. All therapeutic strategies were compared with strategy no intervention". Complications of hypertension (acute myocardial infraction, angina pectoris or stroke alone or in combinations) and total mortality were observed as outcomes. Time horizon of the study was lifetime of the patient or 100 years old, due to assumption that 99% of the cohort would die at that age. Analyses were performed from the third-party payer perspective. Annual discount rate of 5% was applied at all future costs and effects. Undiscounted results showed that patients who started treatment with a beta blocker had the highest life expectancy (49.00 QALY) and being the most cost-effective strategy (ICER = (sic)46.63/QALY compared to no intervention). In the case of discounting the highest gain in the QALY had patients who were on beta blocker, 23.7 QALY. After the discounting cost-effective strategies were ACE inhibitor (ICER = (sic)253.08/QALY compared to no intervention) and diuretic (ICER = (sic)262.54/QALY compared to no intervention). The results of the study showed that the discounting could change the choice of cost-effective therapeutic strategy Biotechnol. & Biotechnol. Eq. 2011, 25(3), 2555-2558", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Biotechnology & Biotechnological Equipment", title = "Impact of discounting in pharmacoeconomic modeling. A case study", volume = "25", number = "3", pages = "2555-2558", doi = "10.5504/BBEQ.2011.0065" }
Lakić, D., Petrova, G., Bogavac-Stanojević, N.,& Jelić-Ivanović, Z.. (2011). Impact of discounting in pharmacoeconomic modeling. A case study. in Biotechnology & Biotechnological Equipment Taylor & Francis Ltd, Abingdon., 25(3), 2555-2558. https://doi.org/10.5504/BBEQ.2011.0065
Lakić D, Petrova G, Bogavac-Stanojević N, Jelić-Ivanović Z. Impact of discounting in pharmacoeconomic modeling. A case study. in Biotechnology & Biotechnological Equipment. 2011;25(3):2555-2558. doi:10.5504/BBEQ.2011.0065 .
Lakić, Dragana, Petrova, Guenka, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, "Impact of discounting in pharmacoeconomic modeling. A case study" in Biotechnology & Biotechnological Equipment, 25, no. 3 (2011):2555-2558, https://doi.org/10.5504/BBEQ.2011.0065 . .