Biomarkers in Serbian patients with Gaucher disease
Samo za registrovane korisnike
2011
Autori
Šumarac, ZoricaSuvajdzić, Nada
Ignjatović, Svetlana
Majkić-Singh, Nada
Janić, Dragana
Petakov, Milan
Đorđević, Maja
Mitrović, Mirjana
Dajak, Marijana
Golubović, Milka
Rodić, Predrag
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.
Ključne reči:
Acid phosphatase / Angiotensin converting enzyme / Chitotriosidase / Enzyme replacement therapy / Ferritin / Gaucher diseaseIzvor:
Clinical Biochemistry, 2011, 44, 12, 950-954Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- Biomarkeri oštećenja i disfunkcije organa (RS-MESTD-Basic Research (BR or ON)-175036)
DOI: 10.1016/j.clinbiochem.2011.05.016
ISSN: 0009-9120
PubMed: 21640089
WoS: 000293043400002
Scopus: 2-s2.0-79960377766
Institucija/grupa
PharmacyTY - JOUR AU - Šumarac, Zorica AU - Suvajdzić, Nada AU - Ignjatović, Svetlana AU - Majkić-Singh, Nada AU - Janić, Dragana AU - Petakov, Milan AU - Đorđević, Maja AU - Mitrović, Mirjana AU - Dajak, Marijana AU - Golubović, Milka AU - Rodić, Predrag PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1553 AB - Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Biomarkers in Serbian patients with Gaucher disease VL - 44 IS - 12 SP - 950 EP - 954 DO - 10.1016/j.clinbiochem.2011.05.016 ER -
@article{ author = "Šumarac, Zorica and Suvajdzić, Nada and Ignjatović, Svetlana and Majkić-Singh, Nada and Janić, Dragana and Petakov, Milan and Đorđević, Maja and Mitrović, Mirjana and Dajak, Marijana and Golubović, Milka and Rodić, Predrag", year = "2011", abstract = "Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Biomarkers in Serbian patients with Gaucher disease", volume = "44", number = "12", pages = "950-954", doi = "10.1016/j.clinbiochem.2011.05.016" }
Šumarac, Z., Suvajdzić, N., Ignjatović, S., Majkić-Singh, N., Janić, D., Petakov, M., Đorđević, M., Mitrović, M., Dajak, M., Golubović, M.,& Rodić, P.. (2011). Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 44(12), 950-954. https://doi.org/10.1016/j.clinbiochem.2011.05.016
Šumarac Z, Suvajdzić N, Ignjatović S, Majkić-Singh N, Janić D, Petakov M, Đorđević M, Mitrović M, Dajak M, Golubović M, Rodić P. Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry. 2011;44(12):950-954. doi:10.1016/j.clinbiochem.2011.05.016 .
Šumarac, Zorica, Suvajdzić, Nada, Ignjatović, Svetlana, Majkić-Singh, Nada, Janić, Dragana, Petakov, Milan, Đorđević, Maja, Mitrović, Mirjana, Dajak, Marijana, Golubović, Milka, Rodić, Predrag, "Biomarkers in Serbian patients with Gaucher disease" in Clinical Biochemistry, 44, no. 12 (2011):950-954, https://doi.org/10.1016/j.clinbiochem.2011.05.016 . .