Приказ основних података о документу
Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions
dc.creator | Đekić, Ljiljana | |
dc.creator | Primorac, Marija | |
dc.creator | Jocković, Jelena | |
dc.date.accessioned | 2019-09-02T11:25:44Z | |
dc.date.available | 2019-09-02T11:25:44Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0167-7322 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1572 | |
dc.description.abstract | This study investigated phase behaviour, microstructure and solubilization capacity of pseudo-ternary surfactant/cosurfactant/isopropyl myristate/water systems employing complex mixtures of nonionic surfactants for formation of single-phase microemulsions. The surfactant was PEG-8 caprylic/capric glycerides (Labrasol (R)). A well defined mixture of octoxynol-12 and polysorbate 20 and/or PEG-40 hydrogenated castor oil, available as commercial nonionicsurfactants Solubilisant gamma (R) 2421, Solubilisant gamma (R) 2429 and Cremophor (R) RH 40, respectively, were evaluated as cosurfactants. Surfactant + cosurfactant mixtures were treated as a single component (pseudo-component), since a surfactant-to-cosurfactant weight ratio (Km 50:50) was constant through the study. Phase behaviour study revealed enlargement of single-phase microemulsion area as surfactant + cosurfactant-to-oil weight ratio (SCoS/O) increases. The formation of fully dilutable microemulsions containing the maximum of water incorporation in the surfactant/cosurfactant/oil preconcentrates of W(max) >= 80% w/w, was achieved at SCoS/O 90:10. Microemulsions formed along the single-phase sequence at SCoS/O 90:10 in the presence of different cosurfactants, were characterized using polarized light microscopy, photon correlation spectroscopy (PCS), and rheological measurements. Different performances of complex mixtures of nonionic surfactants in stabilization of single-phase microemulsions were observed only in highly diluted oil-in-water microemulsions area. Investigation of solubilization capacity for poorly soluble drug ibuprofen revealed the critical importance of water-to-surfactant + cosurfactant ratio and penetration of oil at the interface. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Molecular Liquids | |
dc.subject | Microemulsions | en |
dc.subject | Phase behaviour | en |
dc.subject | Rheological behaviour | en |
dc.subject | Solubilization capacity | en |
dc.subject | Droplet size analysis | en |
dc.title | Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јоцковић, Јелена; Приморац, Марија; Ђекић, Љиљана; | |
dc.citation.volume | 160 | |
dc.citation.issue | 2 | |
dc.citation.spage | 81 | |
dc.citation.epage | 87 | |
dc.citation.other | 160(2): 81-87 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000291075700004 | |
dc.identifier.doi | 10.1016/j.molliq.2011.02.010 | |
dc.identifier.scopus | 2-s2.0-79955568241 | |
dc.type.version | publishedVersion |