Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions
Samo za registrovane korisnike
2011
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This study investigated phase behaviour, microstructure and solubilization capacity of pseudo-ternary surfactant/cosurfactant/isopropyl myristate/water systems employing complex mixtures of nonionic surfactants for formation of single-phase microemulsions. The surfactant was PEG-8 caprylic/capric glycerides (Labrasol (R)). A well defined mixture of octoxynol-12 and polysorbate 20 and/or PEG-40 hydrogenated castor oil, available as commercial nonionicsurfactants Solubilisant gamma (R) 2421, Solubilisant gamma (R) 2429 and Cremophor (R) RH 40, respectively, were evaluated as cosurfactants. Surfactant + cosurfactant mixtures were treated as a single component (pseudo-component), since a surfactant-to-cosurfactant weight ratio (Km 50:50) was constant through the study. Phase behaviour study revealed enlargement of single-phase microemulsion area as surfactant + cosurfactant-to-oil weight ratio (SCoS/O) increases. The formation of fully dilutable microemulsions containing the maximum of wat...er incorporation in the surfactant/cosurfactant/oil preconcentrates of W(max) >= 80% w/w, was achieved at SCoS/O 90:10. Microemulsions formed along the single-phase sequence at SCoS/O 90:10 in the presence of different cosurfactants, were characterized using polarized light microscopy, photon correlation spectroscopy (PCS), and rheological measurements. Different performances of complex mixtures of nonionic surfactants in stabilization of single-phase microemulsions were observed only in highly diluted oil-in-water microemulsions area. Investigation of solubilization capacity for poorly soluble drug ibuprofen revealed the critical importance of water-to-surfactant + cosurfactant ratio and penetration of oil at the interface.
Ključne reči:
Microemulsions / Phase behaviour / Rheological behaviour / Solubilization capacity / Droplet size analysisIzvor:
Journal of Molecular Liquids, 2011, 160, 2, 81-87Izdavač:
- Elsevier Science BV, Amsterdam
Finansiranje / projekti:
- Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.1016/j.molliq.2011.02.010
ISSN: 0167-7322
WoS: 000291075700004
Scopus: 2-s2.0-79955568241
Institucija/grupa
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Primorac, Marija AU - Jocković, Jelena PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1572 AB - This study investigated phase behaviour, microstructure and solubilization capacity of pseudo-ternary surfactant/cosurfactant/isopropyl myristate/water systems employing complex mixtures of nonionic surfactants for formation of single-phase microemulsions. The surfactant was PEG-8 caprylic/capric glycerides (Labrasol (R)). A well defined mixture of octoxynol-12 and polysorbate 20 and/or PEG-40 hydrogenated castor oil, available as commercial nonionicsurfactants Solubilisant gamma (R) 2421, Solubilisant gamma (R) 2429 and Cremophor (R) RH 40, respectively, were evaluated as cosurfactants. Surfactant + cosurfactant mixtures were treated as a single component (pseudo-component), since a surfactant-to-cosurfactant weight ratio (Km 50:50) was constant through the study. Phase behaviour study revealed enlargement of single-phase microemulsion area as surfactant + cosurfactant-to-oil weight ratio (SCoS/O) increases. The formation of fully dilutable microemulsions containing the maximum of water incorporation in the surfactant/cosurfactant/oil preconcentrates of W(max) >= 80% w/w, was achieved at SCoS/O 90:10. Microemulsions formed along the single-phase sequence at SCoS/O 90:10 in the presence of different cosurfactants, were characterized using polarized light microscopy, photon correlation spectroscopy (PCS), and rheological measurements. Different performances of complex mixtures of nonionic surfactants in stabilization of single-phase microemulsions were observed only in highly diluted oil-in-water microemulsions area. Investigation of solubilization capacity for poorly soluble drug ibuprofen revealed the critical importance of water-to-surfactant + cosurfactant ratio and penetration of oil at the interface. PB - Elsevier Science BV, Amsterdam T2 - Journal of Molecular Liquids T1 - Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions VL - 160 IS - 2 SP - 81 EP - 87 DO - 10.1016/j.molliq.2011.02.010 ER -
@article{ author = "Đekić, Ljiljana and Primorac, Marija and Jocković, Jelena", year = "2011", abstract = "This study investigated phase behaviour, microstructure and solubilization capacity of pseudo-ternary surfactant/cosurfactant/isopropyl myristate/water systems employing complex mixtures of nonionic surfactants for formation of single-phase microemulsions. The surfactant was PEG-8 caprylic/capric glycerides (Labrasol (R)). A well defined mixture of octoxynol-12 and polysorbate 20 and/or PEG-40 hydrogenated castor oil, available as commercial nonionicsurfactants Solubilisant gamma (R) 2421, Solubilisant gamma (R) 2429 and Cremophor (R) RH 40, respectively, were evaluated as cosurfactants. Surfactant + cosurfactant mixtures were treated as a single component (pseudo-component), since a surfactant-to-cosurfactant weight ratio (Km 50:50) was constant through the study. Phase behaviour study revealed enlargement of single-phase microemulsion area as surfactant + cosurfactant-to-oil weight ratio (SCoS/O) increases. The formation of fully dilutable microemulsions containing the maximum of water incorporation in the surfactant/cosurfactant/oil preconcentrates of W(max) >= 80% w/w, was achieved at SCoS/O 90:10. Microemulsions formed along the single-phase sequence at SCoS/O 90:10 in the presence of different cosurfactants, were characterized using polarized light microscopy, photon correlation spectroscopy (PCS), and rheological measurements. Different performances of complex mixtures of nonionic surfactants in stabilization of single-phase microemulsions were observed only in highly diluted oil-in-water microemulsions area. Investigation of solubilization capacity for poorly soluble drug ibuprofen revealed the critical importance of water-to-surfactant + cosurfactant ratio and penetration of oil at the interface.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Molecular Liquids", title = "Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions", volume = "160", number = "2", pages = "81-87", doi = "10.1016/j.molliq.2011.02.010" }
Đekić, L., Primorac, M.,& Jocković, J.. (2011). Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions. in Journal of Molecular Liquids Elsevier Science BV, Amsterdam., 160(2), 81-87. https://doi.org/10.1016/j.molliq.2011.02.010
Đekić L, Primorac M, Jocković J. Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions. in Journal of Molecular Liquids. 2011;160(2):81-87. doi:10.1016/j.molliq.2011.02.010 .
Đekić, Ljiljana, Primorac, Marija, Jocković, Jelena, "Phase behaviour, microstructure and ibuprofen solubilization capacity of pseudo-ternary nonionic microemulsions" in Journal of Molecular Liquids, 160, no. 2 (2011):81-87, https://doi.org/10.1016/j.molliq.2011.02.010 . .