Effects of oral and intraperitoneal magnesium treatment against cadmiuminduced oxidative stress in plasma of rats
Апстракт
Cadmium (Cd) has been recognised as one of the most important environmental and industrial pollutants, and up-to-date investigations have shown that one of the mechanisms of its toxicity is associated with the induction of oxidative stress. The aim of this study was to determine the connection between acute oral and intraperitoneal exposure to Cd and parameters indicative of oxidative stress in the plasma of rats, as well as to examine the potential protective effect of magnesium (Mg) in conditions of acute oral and intraperitoneal Cd poisoning. The experiment was performed on male albino Wistar rats (n=40) randomly divided into control group, Cd-or group that received 30 mg kg(-1) b.w. Cd by oral gavage, Cd+Mg-or group that orally received 50 mg kg(-1) b.w. Mg one hour before oral Cd, Cd-ip group that received 1.5 mg kg(-1) b.w. Cd intraperitoneally, and Cd+Mg-ip group that intraperitoneally received 3 mg kg(-1) b.w. Mg 10 min before intraperitoneal Cd. The animals were sacrificed 24 ...h after treatment and the following parameters were measured: superoxide-dismutase activity, superoxide anion, total oxidative status, advanced oxidation protein products, and malondialdehyde. All parameters of oxidative stress in rat plasma were negatively affected by Cd treatment with more pronounced negative effects after intraperitoneal treatment, with the exception of superoxide dismutase (SOD) activity. Although both oral and intraperitoneal Mg pretreatment had protective effects, more pronounced beneficial effects were observed after oral administration, since it managed to completely prevent Cd-induced changes in the investigated parameters. The observed results support the use of Mg as potential protective agent against toxic effects caused by Cd.
Кључне речи:
bioelement supplementation / interactions between metals / mechanisms of toxicityИзвор:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2012, 63, 3, 247-254Издавач:
- Inst Medical Research & Occupational Health, Zagreb
Финансирање / пројекти:
- Унапређење и развој хигијенских и технолошких поступака у производњи намирница животињског порекла у циљу добијања квалитетних и безбедних производа конкурентних на светском тржишту (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46009)
DOI: 10.2478/10004-1254-63-2012-2217
ISSN: 0004-1254
PubMed: 23152374
WoS: 000309641400001
Scopus: 2-s2.0-84875799316
Институција/група
PharmacyTY - JOUR AU - Buha, Aleksandra AU - Bulat, Zorica AU - Đukić-Ćosić, Danijela AU - Matović, Vesna PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1626 AB - Cadmium (Cd) has been recognised as one of the most important environmental and industrial pollutants, and up-to-date investigations have shown that one of the mechanisms of its toxicity is associated with the induction of oxidative stress. The aim of this study was to determine the connection between acute oral and intraperitoneal exposure to Cd and parameters indicative of oxidative stress in the plasma of rats, as well as to examine the potential protective effect of magnesium (Mg) in conditions of acute oral and intraperitoneal Cd poisoning. The experiment was performed on male albino Wistar rats (n=40) randomly divided into control group, Cd-or group that received 30 mg kg(-1) b.w. Cd by oral gavage, Cd+Mg-or group that orally received 50 mg kg(-1) b.w. Mg one hour before oral Cd, Cd-ip group that received 1.5 mg kg(-1) b.w. Cd intraperitoneally, and Cd+Mg-ip group that intraperitoneally received 3 mg kg(-1) b.w. Mg 10 min before intraperitoneal Cd. The animals were sacrificed 24 h after treatment and the following parameters were measured: superoxide-dismutase activity, superoxide anion, total oxidative status, advanced oxidation protein products, and malondialdehyde. All parameters of oxidative stress in rat plasma were negatively affected by Cd treatment with more pronounced negative effects after intraperitoneal treatment, with the exception of superoxide dismutase (SOD) activity. Although both oral and intraperitoneal Mg pretreatment had protective effects, more pronounced beneficial effects were observed after oral administration, since it managed to completely prevent Cd-induced changes in the investigated parameters. The observed results support the use of Mg as potential protective agent against toxic effects caused by Cd. PB - Inst Medical Research & Occupational Health, Zagreb T2 - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology T1 - Effects of oral and intraperitoneal magnesium treatment against cadmiuminduced oxidative stress in plasma of rats VL - 63 IS - 3 SP - 247 EP - 254 DO - 10.2478/10004-1254-63-2012-2217 ER -
@article{ author = "Buha, Aleksandra and Bulat, Zorica and Đukić-Ćosić, Danijela and Matović, Vesna", year = "2012", abstract = "Cadmium (Cd) has been recognised as one of the most important environmental and industrial pollutants, and up-to-date investigations have shown that one of the mechanisms of its toxicity is associated with the induction of oxidative stress. The aim of this study was to determine the connection between acute oral and intraperitoneal exposure to Cd and parameters indicative of oxidative stress in the plasma of rats, as well as to examine the potential protective effect of magnesium (Mg) in conditions of acute oral and intraperitoneal Cd poisoning. The experiment was performed on male albino Wistar rats (n=40) randomly divided into control group, Cd-or group that received 30 mg kg(-1) b.w. Cd by oral gavage, Cd+Mg-or group that orally received 50 mg kg(-1) b.w. Mg one hour before oral Cd, Cd-ip group that received 1.5 mg kg(-1) b.w. Cd intraperitoneally, and Cd+Mg-ip group that intraperitoneally received 3 mg kg(-1) b.w. Mg 10 min before intraperitoneal Cd. The animals were sacrificed 24 h after treatment and the following parameters were measured: superoxide-dismutase activity, superoxide anion, total oxidative status, advanced oxidation protein products, and malondialdehyde. All parameters of oxidative stress in rat plasma were negatively affected by Cd treatment with more pronounced negative effects after intraperitoneal treatment, with the exception of superoxide dismutase (SOD) activity. Although both oral and intraperitoneal Mg pretreatment had protective effects, more pronounced beneficial effects were observed after oral administration, since it managed to completely prevent Cd-induced changes in the investigated parameters. The observed results support the use of Mg as potential protective agent against toxic effects caused by Cd.", publisher = "Inst Medical Research & Occupational Health, Zagreb", journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology", title = "Effects of oral and intraperitoneal magnesium treatment against cadmiuminduced oxidative stress in plasma of rats", volume = "63", number = "3", pages = "247-254", doi = "10.2478/10004-1254-63-2012-2217" }
Buha, A., Bulat, Z., Đukić-Ćosić, D.,& Matović, V.. (2012). Effects of oral and intraperitoneal magnesium treatment against cadmiuminduced oxidative stress in plasma of rats. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology Inst Medical Research & Occupational Health, Zagreb., 63(3), 247-254. https://doi.org/10.2478/10004-1254-63-2012-2217
Buha A, Bulat Z, Đukić-Ćosić D, Matović V. Effects of oral and intraperitoneal magnesium treatment against cadmiuminduced oxidative stress in plasma of rats. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2012;63(3):247-254. doi:10.2478/10004-1254-63-2012-2217 .
Buha, Aleksandra, Bulat, Zorica, Đukić-Ćosić, Danijela, Matović, Vesna, "Effects of oral and intraperitoneal magnesium treatment against cadmiuminduced oxidative stress in plasma of rats" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 63, no. 3 (2012):247-254, https://doi.org/10.2478/10004-1254-63-2012-2217 . .