Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats
Abstract
The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright
Keywords:
Filipendula hexapetala / flowers / methanol extract / hepatoprotective activitySource:
Phytotherapy Research, 2012, 26, 7, 1088-1091Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
- Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-MESTD-Basic Research (BR or ON)-173021)
DOI: 10.1002/ptr.3703
ISSN: 0951-418X
PubMed: 22213368
WoS: 000306085700022
Scopus: 2-s2.0-84863715953
Collections
Institution/Community
PharmacyTY - JOUR AU - Cebović, Tatjana AU - Maksimović, Zoran PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1746 AB - The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright PB - Wiley-Blackwell, Hoboken T2 - Phytotherapy Research T1 - Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats VL - 26 IS - 7 SP - 1088 EP - 1091 DO - 10.1002/ptr.3703 ER -
@article{ author = "Cebović, Tatjana and Maksimović, Zoran", year = "2012", abstract = "The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright", publisher = "Wiley-Blackwell, Hoboken", journal = "Phytotherapy Research", title = "Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats", volume = "26", number = "7", pages = "1088-1091", doi = "10.1002/ptr.3703" }
Cebović, T.,& Maksimović, Z.. (2012). Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats. in Phytotherapy Research Wiley-Blackwell, Hoboken., 26(7), 1088-1091. https://doi.org/10.1002/ptr.3703
Cebović T, Maksimović Z. Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats. in Phytotherapy Research. 2012;26(7):1088-1091. doi:10.1002/ptr.3703 .
Cebović, Tatjana, Maksimović, Zoran, "Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats" in Phytotherapy Research, 26, no. 7 (2012):1088-1091, https://doi.org/10.1002/ptr.3703 . .