Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation
Abstract
The present study describes a screening approach in design of microemulsion preconcentrates (self-microemulsifying systems) comprising: PEG-8 caprylic/capric glycerides (Labrasol (R)) (surfactant), PEG-40 hydrogenated castor oil (Cremophor (R) RH40) (cosurfactant) (at surfactant-to-cosurfactant mass ratios 9:1, 7:3, 5:5, 3:7 and 1:9), and 10% w/w or 20% w/w of medium-chain triglycerides or olive oil (oil). The self-microemulsifying ability of the prepared surfactant/cosurfactant/oil mixtures in water and 0.1 M HCl (pH 1.2), was evaluated by droplet size and zeta potential analysis and cross-polarized light microscopy. The formation of microemulsions was observed only in the presence of medium-chain triglycerides at surfactant-to-cosurfactant ratios 7:3 and 5:5 (in the mixtures containing 10% w/w of the oil phase) and 3:7 and 1:9 (when 20% w/w of the same oil was used). The obtained results provide new implications for development of microemulsion preconcentrates suitable as delivery sy...stems for food and pharmaceutical applications.
Keywords:
Microemulsions / self-microemulsifying systems / Labrasol (R) / Cremophor (R) RH40Source:
Tenside Surfactants Detergents, 2013, 50, 6, 409-413Publisher:
- Carl Hanser Verlag, Munich
Funding / projects:
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.3139/113.110272
ISSN: 0932-3414
WoS: 000329008700001
Scopus: 2-s2.0-84889784075
Collections
Institution/Community
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Cirković, Violeta AU - Heleta, Mirjana AU - Krajišnik, Danina AU - Primorac, Marija PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1878 AB - The present study describes a screening approach in design of microemulsion preconcentrates (self-microemulsifying systems) comprising: PEG-8 caprylic/capric glycerides (Labrasol (R)) (surfactant), PEG-40 hydrogenated castor oil (Cremophor (R) RH40) (cosurfactant) (at surfactant-to-cosurfactant mass ratios 9:1, 7:3, 5:5, 3:7 and 1:9), and 10% w/w or 20% w/w of medium-chain triglycerides or olive oil (oil). The self-microemulsifying ability of the prepared surfactant/cosurfactant/oil mixtures in water and 0.1 M HCl (pH 1.2), was evaluated by droplet size and zeta potential analysis and cross-polarized light microscopy. The formation of microemulsions was observed only in the presence of medium-chain triglycerides at surfactant-to-cosurfactant ratios 7:3 and 5:5 (in the mixtures containing 10% w/w of the oil phase) and 3:7 and 1:9 (when 20% w/w of the same oil was used). The obtained results provide new implications for development of microemulsion preconcentrates suitable as delivery systems for food and pharmaceutical applications. PB - Carl Hanser Verlag, Munich T2 - Tenside Surfactants Detergents T1 - Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation VL - 50 IS - 6 SP - 409 EP - 413 DO - 10.3139/113.110272 ER -
@article{ author = "Đekić, Ljiljana and Cirković, Violeta and Heleta, Mirjana and Krajišnik, Danina and Primorac, Marija", year = "2013", abstract = "The present study describes a screening approach in design of microemulsion preconcentrates (self-microemulsifying systems) comprising: PEG-8 caprylic/capric glycerides (Labrasol (R)) (surfactant), PEG-40 hydrogenated castor oil (Cremophor (R) RH40) (cosurfactant) (at surfactant-to-cosurfactant mass ratios 9:1, 7:3, 5:5, 3:7 and 1:9), and 10% w/w or 20% w/w of medium-chain triglycerides or olive oil (oil). The self-microemulsifying ability of the prepared surfactant/cosurfactant/oil mixtures in water and 0.1 M HCl (pH 1.2), was evaluated by droplet size and zeta potential analysis and cross-polarized light microscopy. The formation of microemulsions was observed only in the presence of medium-chain triglycerides at surfactant-to-cosurfactant ratios 7:3 and 5:5 (in the mixtures containing 10% w/w of the oil phase) and 3:7 and 1:9 (when 20% w/w of the same oil was used). The obtained results provide new implications for development of microemulsion preconcentrates suitable as delivery systems for food and pharmaceutical applications.", publisher = "Carl Hanser Verlag, Munich", journal = "Tenside Surfactants Detergents", title = "Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation", volume = "50", number = "6", pages = "409-413", doi = "10.3139/113.110272" }
Đekić, L., Cirković, V., Heleta, M., Krajišnik, D.,& Primorac, M.. (2013). Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation. in Tenside Surfactants Detergents Carl Hanser Verlag, Munich., 50(6), 409-413. https://doi.org/10.3139/113.110272
Đekić L, Cirković V, Heleta M, Krajišnik D, Primorac M. Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation. in Tenside Surfactants Detergents. 2013;50(6):409-413. doi:10.3139/113.110272 .
Đekić, Ljiljana, Cirković, Violeta, Heleta, Mirjana, Krajišnik, Danina, Primorac, Marija, "Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation" in Tenside Surfactants Detergents, 50, no. 6 (2013):409-413, https://doi.org/10.3139/113.110272 . .