Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?
Само за регистроване кориснике
2013
Аутори
Memon, LidijaSpasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Kotur-Stevuljević, Jelena
Simić-Ogrizović, Sanja
Giga, Vojislav
Dopsaj, Violeta
Jelić-Ivanović, Zorana
Spasić, Slavica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P lt 0.011; F = 2.631, P lt 0.017). After adjustment for GFR, the differences were not seen. In CKD patient...s adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.
Кључне речи:
chronic kidney disease / renal transplant recipients / N-terminal pro B-type natriuretic peptide / symmetric dimethylarginine / diastolic dysfunctionИзвор:
Journal of Clinical Laboratory Analysis, 2013, 27, 6, 461-470Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1002/jcla.21628
ISSN: 0887-8013
PubMed: 24218128
WoS: 000326890600007
Scopus: 2-s2.0-84887357761
Институција/група
PharmacyTY - JOUR AU - Memon, Lidija AU - Spasojević-Kalimanovska, Vesna AU - Bogavac-Stanojević, Nataša AU - Kotur-Stevuljević, Jelena AU - Simić-Ogrizović, Sanja AU - Giga, Vojislav AU - Dopsaj, Violeta AU - Jelić-Ivanović, Zorana AU - Spasić, Slavica PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1897 AB - BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P lt 0.011; F = 2.631, P lt 0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor. PB - Wiley, Hoboken T2 - Journal of Clinical Laboratory Analysis T1 - Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients? VL - 27 IS - 6 SP - 461 EP - 470 DO - 10.1002/jcla.21628 ER -
@article{ author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica", year = "2013", abstract = "BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P lt 0.011; F = 2.631, P lt 0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.", publisher = "Wiley, Hoboken", journal = "Journal of Clinical Laboratory Analysis", title = "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?", volume = "27", number = "6", pages = "461-470", doi = "10.1002/jcla.21628" }
Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis Wiley, Hoboken., 27(6), 461-470. https://doi.org/10.1002/jcla.21628
Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis. 2013;27(6):461-470. doi:10.1002/jcla.21628 .
Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?" in Journal of Clinical Laboratory Analysis, 27, no. 6 (2013):461-470, https://doi.org/10.1002/jcla.21628 . .