Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference
Само за регистроване кориснике
2013
Аутори
Zeljković, AleksandraVekić, Jelena
Spasić, Slavica
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Gojković, Tamara
Ardalić, Daniela
Mandić-Marković, Vesna
Cerović, Nikola
Miković, Željko
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P lt 0.001), due to reduction in relative proportion of LDL I (P lt 0.01) and increase of LDL II (P lt 0.001) and IIIA (P lt 0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly d...ecreased (P lt 0.001), with concomitant increase of HDL 3b and 3c subclasses (P lt 0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn.
Кључне речи:
Pregnancy / LDL and HDL subclasses / Small / dense LDL / Newborn sizeИзвор:
Maternal and Child Health Journal, 2013, 17, 3, 556-565Издавач:
- Springer/Plenum Publishers, New York
Финансирање / пројекти:
DOI: 10.1007/s10995-012-1031-x
ISSN: 1092-7875
PubMed: 22527773
WoS: 000316021200022
Scopus: 2-s2.0-84880719948
Институција/група
PharmacyTY - JOUR AU - Zeljković, Aleksandra AU - Vekić, Jelena AU - Spasić, Slavica AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Gojković, Tamara AU - Ardalić, Daniela AU - Mandić-Marković, Vesna AU - Cerović, Nikola AU - Miković, Željko PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1918 AB - Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P lt 0.001), due to reduction in relative proportion of LDL I (P lt 0.01) and increase of LDL II (P lt 0.001) and IIIA (P lt 0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly decreased (P lt 0.001), with concomitant increase of HDL 3b and 3c subclasses (P lt 0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn. PB - Springer/Plenum Publishers, New York T2 - Maternal and Child Health Journal T1 - Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference VL - 17 IS - 3 SP - 556 EP - 565 DO - 10.1007/s10995-012-1031-x ER -
@article{ author = "Zeljković, Aleksandra and Vekić, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Gojković, Tamara and Ardalić, Daniela and Mandić-Marković, Vesna and Cerović, Nikola and Miković, Željko", year = "2013", abstract = "Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P lt 0.001), due to reduction in relative proportion of LDL I (P lt 0.01) and increase of LDL II (P lt 0.001) and IIIA (P lt 0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly decreased (P lt 0.001), with concomitant increase of HDL 3b and 3c subclasses (P lt 0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn.", publisher = "Springer/Plenum Publishers, New York", journal = "Maternal and Child Health Journal", title = "Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference", volume = "17", number = "3", pages = "556-565", doi = "10.1007/s10995-012-1031-x" }
Zeljković, A., Vekić, J., Spasić, S., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Gojković, T., Ardalić, D., Mandić-Marković, V., Cerović, N.,& Miković, Ž.. (2013). Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference. in Maternal and Child Health Journal Springer/Plenum Publishers, New York., 17(3), 556-565. https://doi.org/10.1007/s10995-012-1031-x
Zeljković A, Vekić J, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Gojković T, Ardalić D, Mandić-Marković V, Cerović N, Miković Ž. Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference. in Maternal and Child Health Journal. 2013;17(3):556-565. doi:10.1007/s10995-012-1031-x .
Zeljković, Aleksandra, Vekić, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Gojković, Tamara, Ardalić, Daniela, Mandić-Marković, Vesna, Cerović, Nikola, Miković, Željko, "Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference" in Maternal and Child Health Journal, 17, no. 3 (2013):556-565, https://doi.org/10.1007/s10995-012-1031-x . .