Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease
Samo za registrovane korisnike
2013
Autori
Kotur-Stevuljević, JelenaPeco-Antić, Amira
Spasić, Slavica
Stefanović, Aleksandra
Paripović, Dušan
Kostić, Mirjana
Vasić, Dragan
Vujović, Ana
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Kornić-Ristovski, Danijela
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p lt 0.001) and antioxid...ative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p lt 0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase.
Ključne reči:
Oxidative stress / Hyperlipidemia / Paraoxonase / Intima media thicknessIzvor:
Pediatric Nephrology, 2013, 28, 2, 295-303Izdavač:
- Springer, New York
Finansiranje / projekti:
- Interaktivna uloga dislipidemije, oksidativnog stresa i inflamacije u aterosklerozi i drugim bolestima: genetički i biohemijski markeri (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1007/s00467-012-2323-5
ISSN: 0931-041X
PubMed: 23117581
WoS: 000313431600015
Scopus: 2-s2.0-84875843222
Institucija/grupa
PharmacyTY - JOUR AU - Kotur-Stevuljević, Jelena AU - Peco-Antić, Amira AU - Spasić, Slavica AU - Stefanović, Aleksandra AU - Paripović, Dušan AU - Kostić, Mirjana AU - Vasić, Dragan AU - Vujović, Ana AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Kornić-Ristovski, Danijela PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1943 AB - The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p lt 0.001) and antioxidative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p lt 0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase. PB - Springer, New York T2 - Pediatric Nephrology T1 - Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease VL - 28 IS - 2 SP - 295 EP - 303 DO - 10.1007/s00467-012-2323-5 ER -
@article{ author = "Kotur-Stevuljević, Jelena and Peco-Antić, Amira and Spasić, Slavica and Stefanović, Aleksandra and Paripović, Dušan and Kostić, Mirjana and Vasić, Dragan and Vujović, Ana and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Kornić-Ristovski, Danijela", year = "2013", abstract = "The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p lt 0.001) and antioxidative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p lt 0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase.", publisher = "Springer, New York", journal = "Pediatric Nephrology", title = "Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease", volume = "28", number = "2", pages = "295-303", doi = "10.1007/s00467-012-2323-5" }
Kotur-Stevuljević, J., Peco-Antić, A., Spasić, S., Stefanović, A., Paripović, D., Kostić, M., Vasić, D., Vujović, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V.,& Kornić-Ristovski, D.. (2013). Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease. in Pediatric Nephrology Springer, New York., 28(2), 295-303. https://doi.org/10.1007/s00467-012-2323-5
Kotur-Stevuljević J, Peco-Antić A, Spasić S, Stefanović A, Paripović D, Kostić M, Vasić D, Vujović A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Kornić-Ristovski D. Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease. in Pediatric Nephrology. 2013;28(2):295-303. doi:10.1007/s00467-012-2323-5 .
Kotur-Stevuljević, Jelena, Peco-Antić, Amira, Spasić, Slavica, Stefanović, Aleksandra, Paripović, Dušan, Kostić, Mirjana, Vasić, Dragan, Vujović, Ana, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Kornić-Ristovski, Danijela, "Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease" in Pediatric Nephrology, 28, no. 2 (2013):295-303, https://doi.org/10.1007/s00467-012-2323-5 . .