Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae)
Аутори
Stanojković, TatjanaKolundžija, Branka
Ćirić, Ana D.
Soković, Marina
Nikolić, Dejan
Kundaković, Tatjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Methanolic extract of Satureja kitaibelii Wierzb. ex Heuff. (Lamiaceae) and its major compond rosmarinic acid possessed strong antimicrobial activity against tested bacteria and fungi, and antitumour activity against malignant cells, but without antiproliferative effect on healthy cell line MRC5. Minimal inhibitory concentration (MIC) of methanolic extract was ranged between 0.0125-1.25 mg/ml, while minimal bactericidal concentration (MBC) was of 0.2-5.0 mg/ml and fungicidal (MFC) was 0.15-2.5 mg/ml. The rosmarinic acid exhibited better antimicrobial activity then methanol extract. The most sensitive species to rosmarinic acid were Bacillus cereus and Candida kruzei, while Micrococcus flavus, Trichoderma viride and Aspergillus niger were the most resistant. The methanol extract exhibited strong activity against Fem-x human malignant melanoma cells with an IC50 39.66 +/- 2.71 mu g/ml, and moderate activity against other cancer cell lines (IC50 from 138.06 +/- 0.16 mu g/ml against estrog...en-dependant breast cancer cell lines MDA-MB-361 to 173.15 +/- 0.02 against a human epithelial cervical cancer cells HeLa). Rosmarinic acid arrested G2/M phase cell cycle in Fem-x cells, against which both methanol extract and rosmarinic acid possessed the best cytotoxic activity.
Кључне речи:
Satureja kitaibelii / Rosmarinic acid / Cytotoxicity / Antimicrobial activityИзвор:
Digest Journal of Nanomaterials and Biostructures, 2013, 8, 2, 845-854Издавач:
- Inst Materials Physics, Bucharest
Финансирање / пројекти:
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-Basic Research (BR or ON)-173021)
- Модификатори биолошког одговора у физиолошким и патолошким стањима (RS-MESTD-Basic Research (BR or ON)-175011)
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
Институција/група
PharmacyTY - JOUR AU - Stanojković, Tatjana AU - Kolundžija, Branka AU - Ćirić, Ana D. AU - Soković, Marina AU - Nikolić, Dejan AU - Kundaković, Tatjana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1975 AB - Methanolic extract of Satureja kitaibelii Wierzb. ex Heuff. (Lamiaceae) and its major compond rosmarinic acid possessed strong antimicrobial activity against tested bacteria and fungi, and antitumour activity against malignant cells, but without antiproliferative effect on healthy cell line MRC5. Minimal inhibitory concentration (MIC) of methanolic extract was ranged between 0.0125-1.25 mg/ml, while minimal bactericidal concentration (MBC) was of 0.2-5.0 mg/ml and fungicidal (MFC) was 0.15-2.5 mg/ml. The rosmarinic acid exhibited better antimicrobial activity then methanol extract. The most sensitive species to rosmarinic acid were Bacillus cereus and Candida kruzei, while Micrococcus flavus, Trichoderma viride and Aspergillus niger were the most resistant. The methanol extract exhibited strong activity against Fem-x human malignant melanoma cells with an IC50 39.66 +/- 2.71 mu g/ml, and moderate activity against other cancer cell lines (IC50 from 138.06 +/- 0.16 mu g/ml against estrogen-dependant breast cancer cell lines MDA-MB-361 to 173.15 +/- 0.02 against a human epithelial cervical cancer cells HeLa). Rosmarinic acid arrested G2/M phase cell cycle in Fem-x cells, against which both methanol extract and rosmarinic acid possessed the best cytotoxic activity. PB - Inst Materials Physics, Bucharest T2 - Digest Journal of Nanomaterials and Biostructures T1 - Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae) VL - 8 IS - 2 SP - 845 EP - 854 UR - https://hdl.handle.net/21.15107/rcub_ibiss_1021 ER -
@article{ author = "Stanojković, Tatjana and Kolundžija, Branka and Ćirić, Ana D. and Soković, Marina and Nikolić, Dejan and Kundaković, Tatjana", year = "2013", abstract = "Methanolic extract of Satureja kitaibelii Wierzb. ex Heuff. (Lamiaceae) and its major compond rosmarinic acid possessed strong antimicrobial activity against tested bacteria and fungi, and antitumour activity against malignant cells, but without antiproliferative effect on healthy cell line MRC5. Minimal inhibitory concentration (MIC) of methanolic extract was ranged between 0.0125-1.25 mg/ml, while minimal bactericidal concentration (MBC) was of 0.2-5.0 mg/ml and fungicidal (MFC) was 0.15-2.5 mg/ml. The rosmarinic acid exhibited better antimicrobial activity then methanol extract. The most sensitive species to rosmarinic acid were Bacillus cereus and Candida kruzei, while Micrococcus flavus, Trichoderma viride and Aspergillus niger were the most resistant. The methanol extract exhibited strong activity against Fem-x human malignant melanoma cells with an IC50 39.66 +/- 2.71 mu g/ml, and moderate activity against other cancer cell lines (IC50 from 138.06 +/- 0.16 mu g/ml against estrogen-dependant breast cancer cell lines MDA-MB-361 to 173.15 +/- 0.02 against a human epithelial cervical cancer cells HeLa). Rosmarinic acid arrested G2/M phase cell cycle in Fem-x cells, against which both methanol extract and rosmarinic acid possessed the best cytotoxic activity.", publisher = "Inst Materials Physics, Bucharest", journal = "Digest Journal of Nanomaterials and Biostructures", title = "Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae)", volume = "8", number = "2", pages = "845-854", url = "https://hdl.handle.net/21.15107/rcub_ibiss_1021" }
Stanojković, T., Kolundžija, B., Ćirić, A. D., Soković, M., Nikolić, D.,& Kundaković, T.. (2013). Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae). in Digest Journal of Nanomaterials and Biostructures Inst Materials Physics, Bucharest., 8(2), 845-854. https://hdl.handle.net/21.15107/rcub_ibiss_1021
Stanojković T, Kolundžija B, Ćirić AD, Soković M, Nikolić D, Kundaković T. Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae). in Digest Journal of Nanomaterials and Biostructures. 2013;8(2):845-854. https://hdl.handle.net/21.15107/rcub_ibiss_1021 .
Stanojković, Tatjana, Kolundžija, Branka, Ćirić, Ana D., Soković, Marina, Nikolić, Dejan, Kundaković, Tatjana, "Cytotoxicity and antimicrobial activity of satureja kitaibelii wierzb. Ex heuff (lamiaceae)" in Digest Journal of Nanomaterials and Biostructures, 8, no. 2 (2013):845-854, https://hdl.handle.net/21.15107/rcub_ibiss_1021 .