Polarographic behaviour of fleroxacin and its determination in tablets
Апстракт
Fleroxacin belongs to the third generation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. This generation members are of broader spectrum and greater activity compared to nalidixin and oxicilin acid (1-3). The polarographic behaviour of fleroxacin fas not been studied so far. The extensive polarographic study of fleroxacin was done through the wide pH range from 2.48 to 10.00 (Britton Robinson buffer) by dc and dpp polarography. The waves obtained in this pH range show a different degree of reversibility; being much more irreversible in acid medium than in slightly acid medium, neutral or slightly alkaline medium (almost the same an value was obtained at pH 5 and 8). Since the polarographic wave at pH 8 was better developed and its limiting current better separated from the supporting electrolyte current, this pH was used in analytical purposes. Very good analytical respons was obtained at pH being approximately 9, in BR,... TRIS and borate buffers. The regression equation obtained in borate buffer was y = 5.428 + 4.5360x (r = 0.9993). Determination of fleroxacin in Quinodis tablets was performed by dpp in borate buffer, pH 8.50. The statistical parameters obtained (SD = 3.07 and RSD = 0.8%) show good reproducibility.
Извор:
Journal de Pharmacie de Belgique, 1998, 53, 3, 224-Издавач:
- APB Algemene Pharmaceutische Bond
Институција/група
PharmacyTY - JOUR AU - Milovanović, Lj AU - Kapetanović, Vera AU - Popović, Gordana AU - Aleksić, Mara PY - 1998 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/199 AB - Fleroxacin belongs to the third generation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. This generation members are of broader spectrum and greater activity compared to nalidixin and oxicilin acid (1-3). The polarographic behaviour of fleroxacin fas not been studied so far. The extensive polarographic study of fleroxacin was done through the wide pH range from 2.48 to 10.00 (Britton Robinson buffer) by dc and dpp polarography. The waves obtained in this pH range show a different degree of reversibility; being much more irreversible in acid medium than in slightly acid medium, neutral or slightly alkaline medium (almost the same an value was obtained at pH 5 and 8). Since the polarographic wave at pH 8 was better developed and its limiting current better separated from the supporting electrolyte current, this pH was used in analytical purposes. Very good analytical respons was obtained at pH being approximately 9, in BR, TRIS and borate buffers. The regression equation obtained in borate buffer was y = 5.428 + 4.5360x (r = 0.9993). Determination of fleroxacin in Quinodis tablets was performed by dpp in borate buffer, pH 8.50. The statistical parameters obtained (SD = 3.07 and RSD = 0.8%) show good reproducibility. PB - APB Algemene Pharmaceutische Bond T2 - Journal de Pharmacie de Belgique T1 - Polarographic behaviour of fleroxacin and its determination in tablets VL - 53 IS - 3 SP - 224 UR - https://hdl.handle.net/21.15107/rcub_farfar_199 ER -
@article{ author = "Milovanović, Lj and Kapetanović, Vera and Popović, Gordana and Aleksić, Mara", year = "1998", abstract = "Fleroxacin belongs to the third generation of multiple fluorinated antibacterial quinolone derivatives widely used in the treatment of urinary infections. This generation members are of broader spectrum and greater activity compared to nalidixin and oxicilin acid (1-3). The polarographic behaviour of fleroxacin fas not been studied so far. The extensive polarographic study of fleroxacin was done through the wide pH range from 2.48 to 10.00 (Britton Robinson buffer) by dc and dpp polarography. The waves obtained in this pH range show a different degree of reversibility; being much more irreversible in acid medium than in slightly acid medium, neutral or slightly alkaline medium (almost the same an value was obtained at pH 5 and 8). Since the polarographic wave at pH 8 was better developed and its limiting current better separated from the supporting electrolyte current, this pH was used in analytical purposes. Very good analytical respons was obtained at pH being approximately 9, in BR, TRIS and borate buffers. The regression equation obtained in borate buffer was y = 5.428 + 4.5360x (r = 0.9993). Determination of fleroxacin in Quinodis tablets was performed by dpp in borate buffer, pH 8.50. The statistical parameters obtained (SD = 3.07 and RSD = 0.8%) show good reproducibility.", publisher = "APB Algemene Pharmaceutische Bond", journal = "Journal de Pharmacie de Belgique", title = "Polarographic behaviour of fleroxacin and its determination in tablets", volume = "53", number = "3", pages = "224", url = "https://hdl.handle.net/21.15107/rcub_farfar_199" }
Milovanović, L., Kapetanović, V., Popović, G.,& Aleksić, M.. (1998). Polarographic behaviour of fleroxacin and its determination in tablets. in Journal de Pharmacie de Belgique APB Algemene Pharmaceutische Bond., 53(3), 224. https://hdl.handle.net/21.15107/rcub_farfar_199
Milovanović L, Kapetanović V, Popović G, Aleksić M. Polarographic behaviour of fleroxacin and its determination in tablets. in Journal de Pharmacie de Belgique. 1998;53(3):224. https://hdl.handle.net/21.15107/rcub_farfar_199 .
Milovanović, Lj, Kapetanović, Vera, Popović, Gordana, Aleksić, Mara, "Polarographic behaviour of fleroxacin and its determination in tablets" in Journal de Pharmacie de Belgique, 53, no. 3 (1998):224, https://hdl.handle.net/21.15107/rcub_farfar_199 .