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17 beta-carboxamide steroids - in vitro prediction of human skin permeability and retention using PAMPA technique
(Elsevier Science BV, Amsterdam, 2014)
In this paper, twenty-two 17 beta-carboxamide steroids were synthesized from five corticosteroids (hydrocortisone, prednisolone, methylprednisolone, dexamethasone and betamethasone) in two steps. The first step was periodic ...
Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: In vitro-in silico approach
(Elsevier Science BV, Amsterdam, 2018)
This study aimed to improve dissolution rate of valsartan in an acidic environment and consequently its oral bioavailability by solid dispersion formulation. Valsartan was selected as a model drug due to its low oral ...
Application of biopartitioning micellar chromatography and QSRR modeling for prediction of gastrointestinal absorption and design of novel beta-hydroxy-beta-arylalkanoic acids
(Elsevier Science BV, Amsterdam, 2017)
Gastrointestinal absorption of thirteen novel beta-hydroxy-beta-arylalkanoic acids (HAA) with anti-inflammatory activity was predicted by use of biopartitioning micellar chromatography and compared to ibuprofen. All tested ...
Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells
(Elsevier Science BV, Amsterdam, 2016)
Imidazoline I1 receptor signaling is associated with pathways that regulate cell viability leading to varied cell-type specific phenotypes. We demonstrated that the antihypertensive drug rilmenidine, a selective imidazoline ...
In vitro-in vivo-in silico approach in biopharmaceutical characterization of ibuprofen IR and SR tablets
(Elsevier Science BV, Amsterdam, 2015)
Within the last decades, physiologically based pharmacokinetic models have emerged into a biopharmaceutical toolkit that has been proven useful in understanding how physicochemical, formulation and physiological factors ...
Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers
(Elsevier Science BV, Amsterdam, 2017)
Up to now, the molecular mechanism of the penetration enhancing effect of sucrose esters (SEs) on stratum corneum (SC) has not been explained in details. In this study, variety of surface sensitive techniques, including ...
Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method
(Elsevier Science BV, Amsterdam, 2017)
The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and ...
Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica
(Elsevier Science BV, Amsterdam, 2017)
Aim: The purpose of this study was to evaluate skin permeation and penetration of nonivamide which has been formulated in novel film-forming formulations (FFFs). These formulations aim to prolong the availability of ...
In vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA technique
(Elsevier Science BV, Amsterdam, 2017)
Prediction of gastrointestinal absorption of thirteen newly synthesized beta-hydroxy-beta-arylalkanoic acids (HAA) and ibuprofen was performed using PAMPA test The highest values of PAMPA parameters (%Tand P-app) were ...
Evaluation of powder, solution and suspension layering for the preparation of enteric coated pellets
(Elsevier Science BV, Amsterdam, 2016)
Gastro-resistant pellets were prepared by use of three different drug loading techniques (powder layering, solution layering and suspension layering) and two different enteric coating techniques (powder layering and ...