Претраживање
Приказ резултата 31-40 од 493
Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease
(John Wiley and Sons Inc, 2022)
Aims: GABAergic modulation involved in cognitive processing appears to be substan- tially changed in Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed to assess if negative and positive allosteric ...
Application of in vitro PAMPA technique and in silico computational methods for blood-brain barrier permeability prediction of novel CNS drug candidates
(Elsevier B.V., 2022)
Permeability assessment of small molecules through the blood-brain barrier (BBB) plays a significant role in the development of effective central nervous system (CNS) drug candidates. Since in vivo methods for BBB permeability ...
The evaluation of drug-plasma protein binding interaction on immobilized human serum albumin stationary phase, aided by different computational approaches
(Elsevier B.V., 2022)
The drug-human serum albumin binding interaction was evaluated on a stationary phase immobilized with human serum albumin using a mixture of phosphate buffer (pH 7.0) and acetonitrile modifier as mobile phase. The 33 ...
Sensitivity of three thyrotropin receptor antibody assays in thyroid-associated orbitopathy / Osetljivost tri testa za određivanje antitela na receptor za tireostimulišući hormon kod pacijenata sa orbitopatijom udruženom sa štitnom žlezdom
(Society of Medical Biochemists of Serbia, 2022)
Background: Thyrotropin receptor autoantibodies (TSH-R-Ab) are indispensable biomarkers in the laboratory assessment of thyroid-associated orbitopathy (TAO). Clinical sensitivity of three different assays for TSH-R-Ab ...
Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
(Oxford University Press, 2022)
Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is ...
New copper(II) cyclam complexes with aminocarboxylate co-ligands: Synthesis, characterization, and in vitro antiproliferative and antibacterial studies / Нови комплекси бакaр(ii)-циклама са аминокарбоксилатним колигандима: синтеза, карактеризација и in vitro антипролиферативна и антибактеријска анализа
(Serbian Chemical Society, 2022)
Two new cationic Cu(II) complexes of cyclam (1,4,8,11-tetraaza- cyclotetradecane) and aminocarboxylate coligands glycine or alanine have been synthesized. The complexes were characterized by elemental analysis (C, H and ...
How to Obtain Maximum Environmental Applicability from Natural Silicates
(MDPI, 2022)
Unmodified natural silicates (bentonite, kaolin, clinoptilolite and diatomites) were tested as adsorbents for the organic pollutants in water tables using Methylene Blue (MB) as the model adsorbate. Among the selected ...
A New Look at Novel Cardiovascular Risk Biomarkers: The Role of Atherogenic Lipoproteins and Innovative Antidiabetic Therapies
(MDPI, 2022)
The presence of residual cardiovascular disease (CVD) risk is a current dilemma in clinical practice; indeed, despite optimal management and treatment, a considerable proportion of patients still undergo major CV events. ...
Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis
(Verduci Editore s.r.l, 2022)
Objective: The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation are the key underlying culprits for its onset and progression. ...
Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review
(MDPI, 2022)
Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due ...