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Prediction of blood-brain barrier permeation of alpha-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis
(Elsevier Science BV, Amsterdam, 2015)
Imidazoline receptor ligands are a numerous family of biologically active compounds known to produce central hypotensive effect by interaction with both alpha(2)-adrenoreceptors (alpha(2)-AR) and imidazoline receptors ...
Combined use of biocompatible nanoemulsions and solid microneedles to improve transport of a model NSAID across the skin: In vitro and in vivo studies
(Elsevier Science BV, Amsterdam, 2018)
This study aimed to investigate the potential of lecithin-based nanoemulsions costabilized by sucrose esters, with and without skin pretreatment with stainless steel microneedles, to improve delivery of aceclofenac, as a ...
Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: In vitro-in silico approach
(Elsevier Science BV, Amsterdam, 2018)
This study aimed to improve dissolution rate of valsartan in an acidic environment and consequently its oral bioavailability by solid dispersion formulation. Valsartan was selected as a model drug due to its low oral ...
17 beta-carboxamide steroids - in vitro prediction of human skin permeability and retention using PAMPA technique
(Elsevier Science BV, Amsterdam, 2014)
In this paper, twenty-two 17 beta-carboxamide steroids were synthesized from five corticosteroids (hydrocortisone, prednisolone, methylprednisolone, dexamethasone and betamethasone) in two steps. The first step was periodic ...
Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers
(Elsevier Science BV, Amsterdam, 2017)
Up to now, the molecular mechanism of the penetration enhancing effect of sucrose esters (SEs) on stratum corneum (SC) has not been explained in details. In this study, variety of surface sensitive techniques, including ...
Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method
(Elsevier Science BV, Amsterdam, 2017)
The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and ...