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Pharmaceutical and technological characteristics of barium sulphate tablets -the screening of various formulation factors
(Macedonian Pharmaceutical AssociationFaculty of Pharmacy, Ss Cyril and Methodius University in Skopje, 2022)
Introduction The study examined the development of barium sulphate tablets that do not dissolve in the digestive tract
and are used as a contrasting agent for measuring transit time through the column. The main problem ...
3D printing of carvedilol oral dosage forms using selective laser sintering technique
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
The adjustment of the dose according to the individual
needs of the patient is a unique advantage of 3D printing
technology, which is of particular importance for the
pediatric and geriatric population, due to the diverse ...
From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression ...
Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Multivariate analysis methods are a set of statistical
techniques that allow multiple variables to be tested
simultaneously. This makes them ideal for studying
relationships in large complex datasets. Pharmaceutical
products ...
Data mining implementation in multiparticulate unit systems characterization
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Multiparticulate unit systems (MPUs) represent
versatile drug delivery systems which provide flexible
dosing and reproducible drug release profile (Al-Hashimi
et al., 2018). They are usually filled in capsules/sachets ...
Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Three-dimensional printing (3DP) is an innovative
additive manufacturing technology in the field of
pharmaceuticals that has the potential to provide small
batches of patient-tailored medicines (Wang et al., 2021).
One ...
A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Physiologically based pharmacokinetic (PBPK)
modeling is an evolving tool that has a profound impact on
drug discovery and formulation development processes. A
major advantage of PBPK models is that they have the
ability ...
Digital light processing 3D printing of Hydrochlorothiazide with modified release
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Additive manufacturing also known as 3D printing
gains more attention in scientific research due to its great
advantages in simple and fast producing custom-designed
products. 3D models created with computer-aided ...
Functional characterization of microcrystalline cellulose obtained from the crop residues
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Crop residues (CR) are usually burned in the field,
which causes air pollution, contributes to global warming,
hinders nutrient recycling, and negatively affects soil
microbes through overheating and carbon loss. There ...
The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Direct compression represents a favorable tablet
manufacturing method. However, obtaining satisfactory
mechanical properties of the compacts and drug dissolution
remains a challenge in formulation development,
particularly ...