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Risk factors for clopidogrel high on-treatment platelet reactivity in patients with carotid artery stenosis undergoing endarterectomy
(Elsevier, 2016)
Background: Carotid endarterectomy (CEA) is the standard treatment
for carotid stenosis. Dual antiplatelet therapy, including aspirin and
clopidogrel, has a potential role in reducing the risk of stroke after car-
otid ...
Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques
(Frontiers Media S.A., 2021)
The availability of large human datasets for genome-wide association studies (GWAS) and the advancement of sequencing technologies have boosted the identification of genetic variants in complex and rare diseases in the ...
Prospective Risk Assessment of Medicine Shortages in Europe and Israel: Findings and Implications
(Frontiers Media S.A., 2020)
Introduction: While medicine shortages are complex, their mitigation is more of a challenge. Prospective risk assessment as a means to mitigate possible shortages, has yet to be applied equally across healthcare settings. ...
Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study
(Wiley, Hoboken, 2009)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT center dot Moclobemide (MCB) undergoes extensive both presystemic and systemic metabolism that can be affected by concomitant drugs. center dot Valproic acid (VPA) and carbamazepine ...
Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women
(Termedia Publishing House Ltd, Poznan, 2017)
Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship ...
In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs
(Frontiers Media S.A., 2020)
Rational drug design implies usage of molecular modeling techniques such as pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to explain the activity of biomolecules, define molecular ...
Beneficial outcomes of omega-6 and omega-3 polyunsaturated fatty acids on human health: An update for 2021
(MDPI AG, 2021)
Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate the antioxidant signaling pathway and ...
Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
(Oxford University Press, 2022)
Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is ...
Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe
(Springer Nature, 2020)
CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved in the metabolism of around 30% of allmedications. Importantly, the corresponding genes are highly polymorphic and these genetic differences ...
Arsenic toxicity: Molecular targets and therapeutic agents
(MDPI AG, 2020)
High arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through ...