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Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABA(A) receptors containing the alpha 5 subunit
(Elsevier Science BV, Amsterdam, 2016)
We have synthesized and characterized MP-III-022 ((R)-8-ethynyl 6 (2 fluorophenyl)-N,4-dimethyl4H-benzo[f]imidazo[1,5-alpha][1,4]diazepine-3-carboxamide) in vitro and in vivo as a binding- and efficacy selective positive ...
Catecholaminergic signalling through thymic nerve fibres, thymocytes and stromal cells is dependent on both circulating and locally synthesized glucocorticoids
(Wiley-Blackwell, Hoboken, 2012)
Glucocorticoids have been shown to modulate the expression of noradrenaline metabolizing enzymes and beta(2)- and alpha(1B)-adrenoceptors in a tissue- and cell- specific manner. In the thymus, apart from extensive sympathetic ...
Cardiovascular risk estimated by UKPDS risk engine algorithm in diabetes
(Sciendo, Warsaw, 2018)
Since there is a high prevalence of type 2 diabetes mellitus (DM2), as well as CVD in Montenegro, we aimed to estimate CVD risk by United Kingdom Prospective Diabetes Study (UKPDS) risk engine algorithm in individuals with ...
Retinol-binding protein 4 versus albuminuria as predictors of estimated glomerular filtration rate decline in patients with type 2 diabetes
(Wolters Kluwer Medknow Publications, Mumbai, 2018)
Background:Since the increase in some tubular damage biomarkers can be observed at the early stage of diabetic nephropathy, even in the absence of albuminuria, we aimed to investigate if urinary albumin is superior than ...
Experimental design in chromatographic analysis of pramipexole and its impurities
(Slovensko Kemijsko Drustvo, Ljubljana, 2007)
Pramipexole is a dopamine D2-agonist/antiparkinsonian agent in which BI-II 546 CL, BI-II 751 xx and 2-amino benzothiazole are commonly found as impurities. Due to the lack of analytical data on pramipexole and its related ...
Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
(Hindawi Publishing Corporation, New York, 2013)
Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different ...
LraI from Lactococcus raffinolactis BGTRK10-1, an Isoschizomer of EcoRI, Exhibits Ion Concentration-Dependent Specific Star Activity
(Hindawi Ltd, London, 2018)
Restriction enzymes are the main defence system against foreign DNA, in charge of preserving genome integrity. Lactococcus raffinolactis BGTRK10-1 expresses LraI Type II restriction-modification enzyme, whose activity is ...
Intrinsic and Extrinsic Thymic Adrenergic Networks: Sex Steroid-Dependent Plasticity
(Frontiers Media Sa, Lausanne, 2018)
The thymus is sexually differentiated organ providing microenvironment for T-cell precursor differentiation/maturation in the major histocompatibility complex-restricted self-tolerant T cells. With increasing age, the ...
Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol
(Slovensko Kemijsko Drustvo, Ljubljana, 2008)
Paracetamol, analgoantipyretic and anti-inflammatory drug, is available in numerous pharmaceutical formulations in common combination with caffeine and some other drug substances. p-aminophenol is paracatamol's process-related ...
Profiling of microorganism-binding serum antibody specificities in professional athletes
(Public Library Science, San Francisco, 2018)
The goal of this work was to elucidate similarities between microorganisms from the perspective of the humoral immune system reactivity in professional athletes. The reactivity of serum IgG of 14 young, individuals was ...