Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants
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2014
Authors
Keck, Cornelia M.Kovacević, Anđelka
Mueller, Rainer H.
Savić, Snežana
Vuleta, Gordana
Milić, Jela
Article (Published version)
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Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility. Thus they seem to be excellent stabilizers for lipid nanoparticles for dermal application. To investigate this, different APGs were selected to evaluate their influence on the formation and characteristics of solid lipid nanoparticles (SLN). Contact angle analysis of the aqueous solutions/dispersions of the APGs on cetyl palmitate films revealed good wettability for all APG surfactants. Cetyl palmitate based SLN were prepared by hot high pressure homogenization and subjected to particle size, charge and inner structure analysis. 1% of each APG was sufficient to obtain SLN with a mean size between 150 nm and 175 nm and a narrow size distribution. The zeta potential in water was similar to -50 mV; the values in the original medium were distinctly lower, but still sufficient high to provide good physical stability. Physical stability at different temperatures (5 degrees C, 25 degrees C an...d 40 degrees C) was confirmed by a constant particle size over an observation period of 90 days in all dispersions. In comparison to SLN stabilized with classical surfactants, e.g., Polysorbate, APG stabilized SLN possess a smaller size, improved physical stability and contain less surfactant. Therefore, the use of APGs for the stabilization of lipid nanoparticles is superior in comparison to classical stabilizers. Further, the results indicate that the length of the alkyl chain of the APG influences the diminution efficacy, the final particle size and the crystallinity of the particles. APGs with short alkyl chain led to a faster reduction in size during high pressure homogenization, to a smaller particle size of the SLN and to a lower recrystallization index, i.e., to a lower crystallinity of the SLN. The crystallinity of the SLN increased with an increase in the alkyl chain length of APGs. Therefore, by using the tested APGs differing in the alkyl chain length, not only small sized and physically stable but also SLN with different sizes and crystallinity can be obtained. An optimized selection of these stabilizers might therefore enable the production of lipid nanoparticles with "tailor-made" properties.
Keywords:
Solid lipid nanoparticles / SLN / Alkyl polyglucosides / Size / Crystallinity / Physical stabilitySource:
International Journal of Pharmaceutics, 2014, 474, 1-2, 33-41Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
- German Academic Exchange Service (DAAD)
DOI: 10.1016/j.ijpharm.2014.08.008
ISSN: 0378-5173
PubMed: 25108048
WoS: 000342681700005
Scopus: 2-s2.0-84906079253
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PharmacyTY - JOUR AU - Keck, Cornelia M. AU - Kovacević, Anđelka AU - Mueller, Rainer H. AU - Savić, Snežana AU - Vuleta, Gordana AU - Milić, Jela PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2078 AB - Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility. Thus they seem to be excellent stabilizers for lipid nanoparticles for dermal application. To investigate this, different APGs were selected to evaluate their influence on the formation and characteristics of solid lipid nanoparticles (SLN). Contact angle analysis of the aqueous solutions/dispersions of the APGs on cetyl palmitate films revealed good wettability for all APG surfactants. Cetyl palmitate based SLN were prepared by hot high pressure homogenization and subjected to particle size, charge and inner structure analysis. 1% of each APG was sufficient to obtain SLN with a mean size between 150 nm and 175 nm and a narrow size distribution. The zeta potential in water was similar to -50 mV; the values in the original medium were distinctly lower, but still sufficient high to provide good physical stability. Physical stability at different temperatures (5 degrees C, 25 degrees C and 40 degrees C) was confirmed by a constant particle size over an observation period of 90 days in all dispersions. In comparison to SLN stabilized with classical surfactants, e.g., Polysorbate, APG stabilized SLN possess a smaller size, improved physical stability and contain less surfactant. Therefore, the use of APGs for the stabilization of lipid nanoparticles is superior in comparison to classical stabilizers. Further, the results indicate that the length of the alkyl chain of the APG influences the diminution efficacy, the final particle size and the crystallinity of the particles. APGs with short alkyl chain led to a faster reduction in size during high pressure homogenization, to a smaller particle size of the SLN and to a lower recrystallization index, i.e., to a lower crystallinity of the SLN. The crystallinity of the SLN increased with an increase in the alkyl chain length of APGs. Therefore, by using the tested APGs differing in the alkyl chain length, not only small sized and physically stable but also SLN with different sizes and crystallinity can be obtained. An optimized selection of these stabilizers might therefore enable the production of lipid nanoparticles with "tailor-made" properties. PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants VL - 474 IS - 1-2 SP - 33 EP - 41 DO - 10.1016/j.ijpharm.2014.08.008 ER -
@article{ author = "Keck, Cornelia M. and Kovacević, Anđelka and Mueller, Rainer H. and Savić, Snežana and Vuleta, Gordana and Milić, Jela", year = "2014", abstract = "Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility. Thus they seem to be excellent stabilizers for lipid nanoparticles for dermal application. To investigate this, different APGs were selected to evaluate their influence on the formation and characteristics of solid lipid nanoparticles (SLN). Contact angle analysis of the aqueous solutions/dispersions of the APGs on cetyl palmitate films revealed good wettability for all APG surfactants. Cetyl palmitate based SLN were prepared by hot high pressure homogenization and subjected to particle size, charge and inner structure analysis. 1% of each APG was sufficient to obtain SLN with a mean size between 150 nm and 175 nm and a narrow size distribution. The zeta potential in water was similar to -50 mV; the values in the original medium were distinctly lower, but still sufficient high to provide good physical stability. Physical stability at different temperatures (5 degrees C, 25 degrees C and 40 degrees C) was confirmed by a constant particle size over an observation period of 90 days in all dispersions. In comparison to SLN stabilized with classical surfactants, e.g., Polysorbate, APG stabilized SLN possess a smaller size, improved physical stability and contain less surfactant. Therefore, the use of APGs for the stabilization of lipid nanoparticles is superior in comparison to classical stabilizers. Further, the results indicate that the length of the alkyl chain of the APG influences the diminution efficacy, the final particle size and the crystallinity of the particles. APGs with short alkyl chain led to a faster reduction in size during high pressure homogenization, to a smaller particle size of the SLN and to a lower recrystallization index, i.e., to a lower crystallinity of the SLN. The crystallinity of the SLN increased with an increase in the alkyl chain length of APGs. Therefore, by using the tested APGs differing in the alkyl chain length, not only small sized and physically stable but also SLN with different sizes and crystallinity can be obtained. An optimized selection of these stabilizers might therefore enable the production of lipid nanoparticles with "tailor-made" properties.", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants", volume = "474", number = "1-2", pages = "33-41", doi = "10.1016/j.ijpharm.2014.08.008" }
Keck, C. M., Kovacević, A., Mueller, R. H., Savić, S., Vuleta, G.,& Milić, J.. (2014). Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 474(1-2), 33-41. https://doi.org/10.1016/j.ijpharm.2014.08.008
Keck CM, Kovacević A, Mueller RH, Savić S, Vuleta G, Milić J. Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants. in International Journal of Pharmaceutics. 2014;474(1-2):33-41. doi:10.1016/j.ijpharm.2014.08.008 .
Keck, Cornelia M., Kovacević, Anđelka, Mueller, Rainer H., Savić, Snežana, Vuleta, Gordana, Milić, Jela, "Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants" in International Journal of Pharmaceutics, 474, no. 1-2 (2014):33-41, https://doi.org/10.1016/j.ijpharm.2014.08.008 . .